Protein Alignment alpha-Est10 and NLGN2

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 182/597 - (30%)
• Similarity: 253/597 - (42%)
• Gaps: 123/597 - (20%)

  Fly    48 YSVIKTKSGPVRGVKR---NTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PA 108
            :.|:.|..|.||||:|   |.|. |....|..:|:|.||:|..||:.|||...|....:.|: |.
Human    41 FPVVNTAYGRVRGVRRELNNEIL-GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPP 104

  Fly   109 DKPLQTH---------MFF-------RKYA--GSEDCLYLNVYV--------------------K 135
            ..|...|         ::|       ..|.  .||||||||:||                    .
Human   105 ACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDT 169

  Fly   136 DLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVP 199
            |::....:|||::::||.|.  |.:.:|:......: .:|::.|:.||||.|||||..|..  ..
Human   170 DIRDPGKKPVMLFLHGGSYM--EGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA--AK 230

  Fly   200 GNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVL 264
            ||.||.|||.||||:.:||..||||...||:||..||.:..:.|.||..:|||..|||..||:.:
Human   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   265 CPWT---QPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFA 326
            ..|:   ||.:  :...||.|:|...::..:|: |.||.....|:|       ..|.:..|...|
Human   296 SSWSVNYQPLK--YTRLLAAKVGCDREDSAEAV-ECLRRKPSRELV-------DQDVQPARYHIA 350

  Fly   327 FGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPE-------VSRRPATLDE 384
            |||||     :..||...|..|||........|:.|....|||.|..:       ||........
Human   351 FGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   385 VGNCKNLLPSDLGLNLDPKLRENYGLQLKKAY--FGDEPCNQANMMKFLELCSYREFWHP-IYRA 446
            .....||.....|.::   |||.    :|..|  :.|....:......|.|.:..::..| :..|
Human   411 SNFVDNLYGYPEGKDV---LRET----IKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATA 468

  Fly   447 ALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGH-QMRGVCHGDDLCYIFHSMLSHQSAPD---- 506
            .|:...||  |.|.|.|.|.   |.|.     |. :.....|||:|.|:|.  :....|.|
Human   469 KLHADYQS--PVYFYTFYHH---CQAE-----GRPEWADAAHGDELPYVFG--VPMVGATDLFPC 521

  Fly   507 --SPEHKVITGMV-DVWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKI 568
              |....:::.:| ..||:||..||||....:..||  |....|        :||
Human   522 NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF--IHTKPN--------RFE---------- 566

  Fly   569 EPVWNSFYAPNK 580
            |.||:.|.:..|
Human   567 EVVWSKFNSKEK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	171/547 (31%)
NLGN2	NP_065846.1	COesterase	42..601	CDD:395084	182/596 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835