DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and tg

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001316794.1	Gene:	tg / 567631	ZFINID:	ZDB-GENE-030519-1	Length:	2733	Species:	Danio rerio

Alignment Length:	564	Identity:	147/564 - (26%)
Similarity:	217/564 - (38%)	Gaps:	142/564 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PVRG--VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVE---PWDQEL---DCTSPADKPLQ 113
            |:.|  .||.|.:.|       :|:|:||:|||||..|:..:   .|:...   .|..|.|
Zfish  2182 PITGSDSKRVTYFLG-------VPYARPPIGDLRFSPPQPADWTGTWNATFFRSSCLQPGD---- 2235

  Fly   114 THMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIV 177
                ....:.|||||||||:|.. ...|..||:|:.:..|       .|:....:..: .::::|
Zfish  2236 ----LTDSSSSEDCLYLNVFVAS-SVAKNAPVLVFFHNSG-------SDLLDGSYLAAVGNIIVV 2288

  Fly   178 TVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGG--AST 240
            |.::|:.|.||||.....|  |||.||:||..||.|||:||..||||...:|:..|..|.  ||.
Zfish  2289 TASFRMAAFGFLSAGSSAL--PGNYGLQDQAAALGWVQKNIALFGGDPTKVTVGAERNGADIASL 2351

  Fly   241 HFLALSPQTEGLIHKAIVMSGSVLCP---WTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMS 302
            |.  .||....|..:|::|.|||..|   .:..........||::|.....:..: :.:.|||..
Zfish  2352 HL--TSPSASSLFSRALLMGGSVFSPAVVMSSSKAQAQTSSLARELDCQAADPSQ-LLDCLRSKP 2413

  Fly   303 GGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFE 367
            ...|..|...:|:....    |.|:.|||     :..||.:.|...:|:...|:..::.|.:..:
Zfish  2414 AHSINAAQTKLLAVSGP----LQAWSPVV-----DGNVVREMPSVALQSGRFHKAEILLGSSFED 2469

  Fly   368 GLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLE 432
            ||     :||       ..|.||.  ..|....|.|..  :...|..:..||:    ||  .|::
Zfish  2470 GL-----ISR-------AKNIKNF--EQLQGRADSKTA--FYAALSNSLGGDD----AN--AFVK 2512

  Fly   433 LCSYREFWHPIYRAALNRVRQSSAPTYLYRFDH----------DSKLCNAIR--IVLC------- 478
                                  .|.|:.|...|          ...|.||.|  .::|
Zfish  2513 ----------------------EAATWFYSLQHSPTPSGYNVFSRALENATRDLFIICPTVDMAE 2555

  Fly   479 ---GHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCESIKSLKFA 540
               .:...||       |::|  |...:|.:|.:..|   .:||...|   |.|.....:.| |:
Zfish  2556 FWAANTQTGV-------YMYH--LPENAAYNSVDLSV---PMDVQYLF---GVPLAAEQRDL-FS 2604

  Fly   541 PIENVTNFKCLNIGDQFEVMALPELQ---------KIEPVWNSF 575
            ..|.....:.:|....|.....|.|.         |..|.|..|
Zfish  2605 YKEKTFTLQIMNYMANFIKSGNPNLPLAASRTSFGKFLPPWPQF 2648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	138/520 (27%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	50/152 (33%)
tg	NP_001316794.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930