Protein Alignment alpha-Est10 and NLGN3

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 167/633 - (26%)
• Similarity: 239/633 - (37%)
• Gaps: 176/633 - (27%)

  Fly    51 IKTKSGPVRGVK---RNTIWG--GSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PAD 109
            :.|..|.:||.:   .:.|.|  ..|..   :|:|.||:|:.||..||....|....:.|. |..
Human    44 VNTHFGKLRGARVPLPSEILGPVDQYLG---VPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPV 105

  Fly   110 KPLQTH---------MFFRK---------YAGSEDCLYLNVYV---------------------- 134
            .|...|         ::|..         ...:||||||||||
Human   106 CPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICR 170

  Fly   135 ---------------------KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIV 177
                                 :|::....:||||:|:||.|.  |.:.:|.......| .:|:::
Human   171 KGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYM--EGTGNMIDGSILASYGNVIVI 233

  Fly   178 TVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHF 242
            |:.||:|.|||||..|..  ..||.||.|||.|||||.:||..||||...||:||...|.:....
Human   234 TLNYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSL 296

  Fly   243 LALSPQTEGLIHKAIVMSGSVLCPWT---QPPRNNWAYRLAQKLGYTG-DNKDKAIFEFLRSMSG 303
            |.||..:|||..:||:.|||.|..|.   ||.:  :...||.|:|... |..|  :.:.||..|.
Human   297 LTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVK--YTSLLADKVGCNVLDTVD--MVDCLRQKSA 357

  Fly   304 GEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEG 368
            .|:|:       .|.:..|...|||||:     :..|:...|..||:........:|.|....||
Human   358 KELVE-------QDIQPARYHVAFGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEG 410

  Fly   369 LLFY-----PEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAY--FGDEPCNQAN 426
            |.|.     ||........|.  :..|.:.:..|.   |:.::.....:|..|  :.|....:..
Human   411 LKFVEGVVDPEDGVSGTDFDY--SVSNFVDNLYGY---PEGKDTLRETIKFMYTDWADRDNPETR 470

  Fly   427 MMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMR----GVCH 487
            ....:.|.:..::..|....|....|..| |||.|.|.|.           |...|:    ...|
Human   471 RKTLVALFTDHQWVEPSVVTADLHARYGS-PTYFYAFYHH-----------CQSLMKPAWSDAAH 523

  Fly   488 GDDLCYIFHSMLSHQSAPDSPEHKVITGMVDV-------------------WTSFAAHGDPNCES 533
            ||::.|:|       ..|       :.|..|:                   ||:||..||||
Human   524 GDEVPYVF-------GVP-------MVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPN--- 571

  Fly   534 IKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFYAPNKL 581
                  .|:...|.| .....::||          |..|:.:...::|
Human   572 ------KPVPQDTKF-IHTKANRFE----------EVAWSKYNPRDQL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	159/583 (27%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	167/633 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		1/24 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694