DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Cesl1

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	158/530 - (29%)
Similarity:	229/530 - (43%)	Gaps:	95/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWG--GSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELD-------CT 105
            |:.|..|.|.| |..::.|  .|...|..:||||||:|.|||..|:..|||....:       |:
  Rat    60 VVDTMKGKVLG-KYASLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCS 123

  Fly   106 SPADK-----------PLQTHMFFRKYAGSEDCLYLNVYV-KDLQPDKLRPVMVWIYGGGYQVGE 158
            ..|.|           ..:.|:.|     ||||||||:|. .|...|...||||||:|||...|.
  Rat   124 QDATKGQRMNDLLTNRKEKVHLQF-----SEDCLYLNIYTPADFTKDSRMPVMVWIHGGGLTQGG 183

  Fly   159 ASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFG 222
            ||  .|......: ::||:|.:.||||..||.|..|....  ||.|..||:.||.|||.||..||
  Rat   184 AS--TYDGQVLSAYENVVVVAIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHWVQDNIANFG 244

  Fly   223 GDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCP--WTQPPRNNWAYRLAQKLGY 285
            ||..::|:|||||||.|...|.|||.::.|.|:||..||.||..  :|:..|.. |.::|...|.
  Rat   245 GDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISESGVVLITELFTKDVRPA-AKQIADMAGC 308

  Fly   286 TGDN--------KDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVA 342
            ....        :.|...|.|..|....::|.::. ....|.:|.:......||.|
  Rat   309 KTTTSAIIVHCLRQKTEEELLEIMEKMNLIKLSSQ-RDTKESYHFLSTVIDDVVLP--------- 363

  Fly   343 KQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLN------LD 401
            |.|.|::.....:.:|.:.|....|.....|.:.|             .:|.|:.|:      |.
  Rat   364 KDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMR-------------FVPPDVKLDKKMAIMLL 415

  Fly   402 PKLRENYGL-------QLKKAYFG-DEPCN-QANMMKFLELCSYREFWHPIYRAALNRVRQSSAP 457
            .|....||:       .::|...| |:|.. :..::.|:   ....|..|....:.:. |.:.||
  Rat   416 EKFASIYGIPEDIIPVAIEKYRKGSDDPIKIRDGILAFI---GDALFCIPSVMVSRDH-RDAGAP 476

  Fly   458 TYLYRFDHDSKLCNAIRIVLCGHQMRGVC--HGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVW 520
            ||:|.:.:.....:..|       .:.|.  |.||:..:|.:.:....|.:. |.|:...::..|
  Rat   477 TYVYEYQYYPSFSSPQR-------PKDVVGDHADDVYSVFGAPILRDGASEE-EIKLSKMVMKFW 533

  Fly   521 TSFAAHGDPN 530
            .:||.:|:||
  Rat   534 ANFARNGNPN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	158/530 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	67/150 (45%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	158/530 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000