DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces2h

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	166/561 - (29%)
Similarity:	234/561 - (41%)	Gaps:	117/561 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ISFKYEQRKLSTAIYSVI-------KTKSGPVRGVKRNTIWGG---------SYFSFEKIPFAKP 82
            :..|....:|:||...::       :....|:|......|.|.         ...||..||||||
  Rat     1 MGLKQIHARLTTAACGLLLLLQVQGQDSLSPIRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKP 65

  Fly    83 PVGDLRFKAPEAVEPWDQELDCTSPADKPLQ--THMFFRKY----------AGSEDCLYLNVYVK 135
            |:|.|||..|||.|||....|.||.....||  |.|..:.:          ..||||||||:|.
  Rat    66 PIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYT- 129

  Fly   136 DLQPDKLR-----PVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDP 194
               |:...     ||||||:||...:|.||  :|......: ::||:||:.||||.|||.|..|.
  Rat   130 ---PNHAHEGSNLPVMVWIHGGALVIGMAS--LYDGSMLAAMENVVVVTIQYRLGVLGFFSTGDQ 189

  Fly   195 QLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVM 259
              :..||.|..||:.||.||||||..|||:.:.:|:|||||||.|.....:||.:.||.|.||:.
  Rat   190 --HARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIME 252

  Fly   260 SGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRIL 324
            ||..|........::..||....|........||:...||..|..||:..        .|..||:
  Rat   253 SGVALMSSLISVSSDVVYRTVANLSGCEQVDSKALVNCLRGKSEEEIMSI--------NKAFRII 309

  Fly   325 FAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCK 389
            ...        .:...:.:.|.||:.::..|.||.:.|..:                 ||.|
  Rat   310 SGI--------VDGIFLPRHPKELLASADFHPIPSIIGVNN-----------------DEYG--- 346

  Fly   390 NLLPSDLGLNLDPKLRENYGLQ-------------------LKKAYFGDEPCNQANMMKFLELCS 435
            .::||.:......|..:...:|                   |.:.|.||....|...::|.|:..
  Rat   347 WIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMGDSEDPQFLQVQFKEMME 411

  Fly   436 YREFWHPIYRAALNRVRQSSAPTYLYRFDH------DSKLCNAIRIVLCGHQMRGVCHGDDLCYI 494
            ...|..|..:.|  ..::|:||.|.|.|.|      |||..:.           ...|||::.:|
  Rat   412 DFTFVIPALQVA--HFQRSNAPVYFYEFQHRPSFFKDSKPPHV-----------KADHGDEILFI 463

  Fly   495 FHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHGDPNCESI 534
            |.|.........:.|.:::: .|:..|.:||..|:||.|.:
  Rat   464 FRSFWGGTQVDLTEEEELLSRRMMKYWANFARQGNPNSEGL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	162/546 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	63/152 (41%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	162/532 (30%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	49/110 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740