Protein Alignment alpha-Est10 and ACHE

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 169/552 - (30%)
• Similarity: 250/552 - (45%)
• Gaps: 99/552 - (17%)

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ- 113
            ::..:.|.:||::..|. ||...:|..||||:||:|..||..||..:||...:|.|:......|
Human   107 LVTVRGGRLRGIRLKTP-GGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQY 170

  Fly   114 ----------THMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDF 168
                      |.|:......|||||||||:....:|....||:|||||||:..|.:|.|:|...|
Human   171 VDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRF 235

  Fly   169 FMSKD-VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFG 232
            .:..: .|:|::.||:||.|||:|...: ..|||.||.||.:||:|||:|:.|||||..::||||
Human   236 LVQAERTVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFG 299

  Fly   233 ESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKL--------GYTGDN 289
            ||||.||.....|||.:.||.|:|::.||:...||....... |.|.|.:|        |.||.|
Human   300 ESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGE-ARRRATQLAHLVGCPPGGTGGN 363

  Fly   290 KDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRIL-------FAFGPVVEPYTTEHTVVAKQPHE 347
             |..:...||:        ..|.||.|.|.|  :|       |:|.|||     :...::..|..
Human   364 -DTELVACLRT--------RPAQVLVNHEWH--VLPQESVFRFSFVPVV-----DGDFLSDTPEA 412

  Fly   348 LMQNSWSHRIPMMFGGTSFEGLLFY----PEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENY 408
            |:.....|.:.::.|....||..|.    |..|:...:|  :...:.|....:|:   |:: .:.
Human   413 LINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESL--ISRAEFLAGVRVGV---PQV-SDL 471

  Fly   409 GLQLKKAYFGD--EPCNQANMMKFLE--------LCSYREFWHPIYRAALNRVRQSSAPTYLYRF 463
            ..:....::.|  .|.:.|.:.:.|.        :|       |:.:.| .|:....|..|.|.|
Human   472 AAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVC-------PVAQLA-GRLAAQGARVYAYVF 528

  Fly   464 DHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHG 527
            :|.:.       .|......||.||.::.:||...|. .|...:.|.|:.. .::..|.:||..|
Human   529 EHRAS-------TLSWPLWMGVPHGYEIEFIFGIPLD-PSRNYTAEEKIFAQRLMRYWANFARTG 585

  Fly   528 DPN----------------CESIKSLKFAPIE 543
            |||                .:...||...|:|
Human   586 DPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLE 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	165/540 (31%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	169/552 (31%)
		AChE_tetra	645..678	CDD:430146