DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and ACHE

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	552	Identity:	169/552 - (30%)
Similarity:	250/552 - (45%)	Gaps:	99/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ- 113
            ::..:.|.:||::..|. ||...:|..||||:||:|..||..||..:||...:|.|:......|
Human   107 LVTVRGGRLRGIRLKTP-GGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQY 170

  Fly   114 ----------THMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDF 168
                      |.|:......|||||||||:....:|....||:|||||||:..|.:|.|:|...|
Human   171 VDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRF 235

  Fly   169 FMSKD-VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFG 232
            .:..: .|:|::.||:||.|||:|...: ..|||.||.||.:||:|||:|:.|||||..::||||
Human   236 LVQAERTVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFG 299

  Fly   233 ESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKL--------GYTGDN 289
            ||||.||.....|||.:.||.|:|::.||:...||....... |.|.|.:|        |.||.|
Human   300 ESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGE-ARRRATQLAHLVGCPPGGTGGN 363

  Fly   290 KDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRIL-------FAFGPVVEPYTTEHTVVAKQPHE 347
             |..:...||:        ..|.||.|.|.|  :|       |:|.|||     :...::..|..
Human   364 -DTELVACLRT--------RPAQVLVNHEWH--VLPQESVFRFSFVPVV-----DGDFLSDTPEA 412

  Fly   348 LMQNSWSHRIPMMFGGTSFEGLLFY----PEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENY 408
            |:.....|.:.::.|....||..|.    |..|:...:|  :...:.|....:|:   |:: .:.
Human   413 LINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESL--ISRAEFLAGVRVGV---PQV-SDL 471

  Fly   409 GLQLKKAYFGD--EPCNQANMMKFLE--------LCSYREFWHPIYRAALNRVRQSSAPTYLYRF 463
            ..:....::.|  .|.:.|.:.:.|.        :|       |:.:.| .|:....|..|.|.|
Human   472 AAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVC-------PVAQLA-GRLAAQGARVYAYVF 528

  Fly   464 DHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHG 527
            :|.:.       .|......||.||.::.:||...|. .|...:.|.|:.. .::..|.:||..|
Human   529 EHRAS-------TLSWPLWMGVPHGYEIEFIFGIPLD-PSRNYTAEEKIFAQRLMRYWANFARTG 585

  Fly   528 DPN----------------CESIKSLKFAPIE 543
            |||                .:...||...|:|
Human   586 DPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLE 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	167/549 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	66/147 (45%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	169/552 (31%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840