DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	274/576 - (47%)
Similarity:	360/576 - (62%)	Gaps:	33/576 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PKVFTNGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGS-YFSFEKIPFAKPPV 84
            ||:...|   .|::..|.:|.:|||....::.||.|.|||::|.|::... ||:||.||:|||||
  Fly     8 PKLIKMG---AQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPV 69

  Fly    85 GDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWI 149
            |||||:||:..|||...|:||:...||:|.:|......||||||:||||||.|:.:|..||:|||
  Fly    70 GDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWI 134

  Fly   150 YGGGYQVGEASRDMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWV 214
            ||||:|.||||||:||||:||.|.||.|.:.|||.|||||||.||:|:||||||||||:|||||:
  Fly   135 YGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWI 199

  Fly   215 QQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRL 279
            .|||..|.||.|||||.|||||.||.|.:..:.||.||.||||:.||..|..|.:.|.||||:||
  Fly   200 SQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRL 264

  Fly   280 AQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQ 344
            ||.|||.||.||..:..||..:...:|......|::.||....:|||||||:|||.|:|.||.|:
  Fly   265 AQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKR 329

  Fly   345 PHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYG 409
            ..:|:..:|.:.||::.||.|||||..|..|.:.|..|.   |..|:||.:        :||...
  Fly   330 HKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALK---NFHNILPRE--------VRETSS 383

  Fly   410 LQ--------LKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSA---PTYLYRF 463
            |:        ||:.||.:|......|.:.|.:.|:|:.||..:|..|  .|||.|   |||||||
  Fly   384 LEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFIL--ARQSYAPKTPTYLYRF 446

  Fly   464 DHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGD 528
            |.||...|..|.::||.::|||.|.|:|.|:|:::::.:....|.|:|.|..||.:|||||:.|:
  Fly   447 DFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGN 511

  Fly   529 PNCESIKSLKFAPI---ENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFYAPNKL 581
            |||..:.|.|:..:   ||... ||.||....|:..|||...: .||::||....|
  Fly   512 PNCPELGSAKWEAVQLKENAVE-KCFNISHDLEMRDLPESDCL-AVWDTFYPRESL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	250/504 (50%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	96/146 (66%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	250/503 (50%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	74/103 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467355
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910