DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	276/573 - (48%)
Similarity:	390/573 - (68%)	Gaps:	24/573 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVE 96
            :::.||.:||:..|:..:|:.|..||::||||.:|:|.||||||:|||||||||:||:|||:..|
  Fly    15 KMVDFKVQQRRYRTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPE 79

  Fly    97 PWDQELDCTSPADKPLQTHMFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASR 161
            .|.:...|||...||||.|..|....|||||||||||.|:|.|.|..||||||||||:|.|||||
  Fly    80 VWTEVRSCTSQGPKPLQKHFVFEMTDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASR 144

  Fly   162 DMYSPDFFMSKDVVIVTVAYRLGAL------------------GFLSLDDPQLNVPGNAGLKDQI 208
            :.||||:.:.:|||::::.||||.|                  |||.||||:|:||||||||||:
  Fly   145 ECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQV 209

  Fly   209 MALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRN 273
            :|||||:.|...|||||.|||:||:|||.||.|::.::.||.||.||||.|||:.|.||...|:.
  Fly   210 LALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQR 274

  Fly   274 NWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEH 338
            ||.||||.:.||.|:|..:.::|||::..|.||:||...:..::||..||.|:||||:|||.|.|
  Fly   275 NWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSH 339

  Fly   339 TVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPK 403
            .||.|:|.|:|:.:||:.||::.||.|.||||.|.|....|..|:|:.:|:.::|.:|.::.:..
  Fly   340 CVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRESA 404

  Fly   404 LRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQS-SAPTYLYRFDHDS 467
            |...||.||::.|:||:..:...:.::|::.|:..||.||||..|:|::.: ||||||||||.||
  Fly   405 LCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDS 469

  Fly   468 KLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCE 532
            |..|.:||:.||.::||.||||||.|:|::.|:.:....:.|:|.|..:|.:||.|||.|:||.:
  Fly   470 KHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFD 534

  Fly   533 SIKSLKFAPIENVT----NFKCLNIGDQFEVMALPELQKIEPVWNSFYAPNKL 581
            ..:...:.|::...    ..|||||.|:.:|:.:|:|:|: .||.||:..::|
  Fly   535 PEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDVPDLKKL-MVWESFFRRDEL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	255/511 (50%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	92/164 (56%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	256/521 (49%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	69/121 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467340
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910