DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Nrt

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	140/564 - (24%)
Similarity:	209/564 - (37%)	Gaps:	146/564 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPL 112
            |.:..|..|||.|||.:     ..|:|..||:|||||..||:|..|.::      |.....:..|
  Fly   360 YIMAVTGCGPVEGVKED-----GAFAFRGIPYAKPPVDRLRWKPAELID------DINMCWNDTL 413

  Fly   113 QTH---------MFFRKYAGSEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPD- 167
            |||         :......|.||||||:|....::.:...||:|.|  |...:...|..:..|.
  Fly   414 QTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLI--GAESLAGPSPGILRPSA 476

  Fly   168 -FFMSKDVVIVTVAYRLGALGFLSLD--DPQLNVP--GNAGLKDQIMALRWVQQNIEAFGGDSNN 227
             :..|.||:.|...:|||..|||:||  ..:.:.|  ||..|.|.|..|.|::.||..||||..:
  Fly   477 RYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQS 541

  Fly   228 ITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDK 292
            :||.|..||......|..|.:.:||..:|...|||.:.|             .:.|..:|...::
  Fly   542 VTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP-------------GKPLSESGKQNEQ 593

  Fly   293 -------AIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEH-TVVAKQPHELM 349
                   |..:.||..|...:..||                      |.|..| .|...||.|..
  Fly   594 LMATLECADIQCLREASSERLWAAT----------------------PDTWLHFPVDLPQPQEAN 636

  Fly   350 QNSWSHRIPMMFGGTSFEGLLFYP-EVSRRPATLDEVGNCKNLLPSDLGLNL----DPKLRE--- 406
            .:...|...::.|...||    :| :..:|     |..|.|.:|.  :|...    ..||||
  Fly   637 ASGSRHEWLVLDGDVVFE----HPSDTWKR-----EQANDKPVLV--MGATAHEAHTEKLRELHA 690

  Fly   407 NYGLQLKKAY----------FGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLY 461
            |:..:..:||          ..||...:.|...:..|.|.......:.....|..:|.|.|.|:
  Fly   691 NWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYV- 754

  Fly   462 RFDHDSKLCNAIRIVLCGHQMRGVCHG---DDLCYI---FHSMLSHQSAPDSPEHKVITGMVDVW 520
                                   |..|   |.|..:   ..::|.........:.:.::.|..::
  Fly   755 -----------------------VTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLF 796

  Fly   521 TSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPE 564
            ..:.:||     :::|.       |.|.:.:|:|..    |.||
  Fly   797 YYYVSHG-----TVQSF-------VQNRRVINVGQD----AQPE 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	132/539 (24%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	48/152 (32%)
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	139/562 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810