Protein Alignment alpha-Est10 and AADACL2

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 71/365 - (19%)
• Similarity: 130/365 - (35%)
• Gaps: 111/365 - (30%)

  Fly   102 LDCTSPADKPLQTHMFFRKYAGSEDCLYLNV----YVKDLQPDKLRPVMVWIYGGGYQVGEASRD 162
            ||.|.|...         :|....|..::::    |:...:.:..|..:::.:|||:..|.:.:.
Human    68 LDYTQPLSD---------EYITVTDTTFVDIPVRLYLPKRKSETRRRAVIYFHGGGFCFGSSKQR 123

  Fly   163 MYSPDFFMSK------DVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRW--VQQNIE 219
            .:.   |:::      |.|:|.|.|||.         ||.:.|  |..:|.:.|:::  :::.:.
Human   124 AFD---FLNRWTANTLDAVVVGVDYRLA---------PQHHFP--AQFEDGLAAVKFFLLEKILT 174

  Fly   220 AFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLG 284
            .:|.|...|.:.|:|:||.....:....|.:..|...|.|                     |.|.
Human   175 KYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEIKHKIKM---------------------QVLL 218

  Fly   285 YTGDNKDKAIFEFLRSMSGGEIVKATATVL-SNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHEL 348
            |.|                   ::.|.:.| |:.|..|.|:......::..:...|.....|..:
Human   219 YPG-------------------LQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDEALPWAM 264

  Fly   349 MQN--------------SWSHRIPMMF-----------GGTSFE--GL-------LFYPEVSRRP 379
            .:|              :||..:|..:           ||.|:.  ||       |...:...:.
Human   265 RRNQHMPLESRHLFKFVNWSILLPEKYRKDYVYTEPILGGLSYSLPGLTDSRALPLLANDSQLQN 329

  Fly   380 ATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGD 419
            ..|..:..|::.|..|.||....:|| |.|:|:...:..|
Human   330 LPLTYILTCQHDLLRDDGLMYVTRLR-NVGVQVVHEHIED 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	71/365 (19%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	63/317 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		0/1 (0%)