DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and CG4382

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	175/561 - (31%)
Similarity:	265/561 - (47%)	Gaps:	64/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT 114
            ||.|..|.:||....:..|.::::|..||:|||||..|||:.||.||.|...||.|....|..|.
  Fly    45 VITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQL 109

  Fly   115 HMFFRKYAG--SEDCLYLNVYVKDL----QPDKLRPVMVWIYGGG-YQVGEASRDMYSPDFFMSK 172
            .:    .:|  |||||.:|:|.|:|    ||:..|||:|:|:.|| |.:...|::...|.:||::
  Fly   110 GL----VSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNR 170

  Fly   173 DVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGG 237
            .:|:||..||||:||||:....:  .|||.|||||:..||||:.:|..||||.::|||.|..||.
  Fly   171 RLVLVTFNYRLGSLGFLATGTRE--APGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGA 233

  Fly   238 ASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRN-NWAYRLAQKLGYTGDNKDKAIFEFLRSM 301
            .:.....:||.:.||.||||||||:|...|:.|... :.|.:.|..|....:|    :.|.:..:
  Fly   234 MAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTEN----VTEMMDCL 294

  Fly   302 SGG---EIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGG 363
            .|.   |.......:...|..:..||:.  ||:||...:...:.::|....||....::|::.|.
  Fly   295 KGKHYLEFANTLPKMFEFDRNNPLILWK--PVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGM 357

  Fly   364 T--SFEGLLFYPEVS--RRPATLDEVG-NCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCN 423
            |  .|.|    |.:|  :.|..|..:. |.::|.|.....|.......|...:|:..||.|
  Fly   358 TKDEFVG----PALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYFPD---- 414

  Fly   424 QANMMKFLELCSYREFWHPIYRAALN--------RVRQSSAPTYLYRFDHDSKLCNAIRIVLCGH 480
                 |.::.....|....:|..||.        .:...|...|.|||.:.....:   |.....
  Fly   415 -----KLIDANRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSH---IYYPED 471

  Fly   481 QMRGVCHGDDLCYIF-HSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCE---SIKSLKFAP 541
            ...||.|.|||.|:| ...:|.....|..|.:::..||.::::||..||||..   :::.:::.|
  Fly   472 APYGVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRP 536

  Fly   542 IENVTNFK---CLNIGDQFEVMALPELQKIEPVWNSFYAPN 579
            .    :||   .|:||....:......:..| :|...:..|
  Fly   537 F----SFKKRYYLDIGKHITLEENLNAENYE-IWKRLFPLN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	166/519 (32%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	67/152 (44%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	173/552 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467421
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.740