DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and CG5397

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	134/541 - (24%)
Similarity:	226/541 - (41%)	Gaps:	93/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 IYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKP 111
            |::.:..:...|.|. ||...|  .:||..:.:|:||||.||:..| ..:....:.:.|......
  Fly    52 IFARLFDRDARVEGF-RNPSTG--IYSFLGMHYAEPPVGPLRYSRP-VYKRLAGDFNATKHGPPC 112

  Fly   112 LQTH-MFFRKYAGSEDCLYLNVYVKDLQPDKLR--PVMVWIYGGGYQVGEASRDMYSPDFFMSKD 173
            :|.| .|.::..|.||||.||||...: ||:..  ||.|||:.|||:.|.|::  |.......:.
  Fly   113 IQPHPQFPQRIIGDEDCLLLNVYTPQM-PDETTGLPVFVWIHPGGYRYGSAAQ--YDATPMAQRG 174

  Fly   174 VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGA 238
            .::|...||||:||.:.  |......||..:.|...|||||...|..|||:...:...|..:|.|
  Fly   175 AIVVAPQYRLGSLGIMG--DGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAA 237

  Fly   239 STHFLALSP--QTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSM 301
            |..:|::||  ::.|.:|..:.|||:.|..:........:.:...|:.......:..|...|||.
  Fly   238 SAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNELEIVNCLRSK 302

  Fly   302 SGGEIVKATATVLSNDEKHHRILFA-------------FGPVVEPYTTEH---TVVAKQPHELMQ 350
            |..:|:|       ||:|......|             |.|.:|......   :::..:|.:.::
  Fly   303 SAEDIIK-------NDDKVQTERLAGRALVKGLTGNVGFQPHIESEDDGRALPSLIVGEPEQQLK 360

  Fly   351 NSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEV-GNCKNLL---------------------- 392
            :|....||::.|.|..|     ...|....|:::| |:.:..|
  Fly   361 SSNFSGIPLLTGVTKHE-----TANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQ 420

  Fly   393 ---PSDLGLN--LDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVR 452
               |...||.  |.|.|::.:  ::.:|...|:.     :.|.:|  |..:....:......:|.
  Fly   421 IAKPELPGLTSVLTPTLQDVW--KVPQALNVDQV-----LSKVVE--STTDVLFNLPAVLTTQVW 476

  Fly   453 QSSAPTYLYRFDHD---SKLCNAIR----IVLCGH-QMRGVCHGDDLCY------IFHSMLSHQS 503
            ...||.::|.|:::   ||..|.::    :....| :...|.|||::.|      ||.:.:....
  Fly   477 SRLAPAFMYSFEYNGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETR 541

  Fly   504 APDSPEHKVITGMVDVWTSFA 524
            ...:.:.||...::|:...||
  Fly   542 LTSAEDLKVRNNLIDLLVKFA 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	133/539 (25%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	48/150 (32%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	133/531 (25%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	63/184 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	5	4.810