DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and cel.1

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	531	Identity:	162/531 - (30%)
Similarity:	246/531 - (46%)	Gaps:	68/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKA 91
            |.||..|:.....|    .|....:.|:.|.|:|..|:........:|:.||||.||   .||:.
Zfish     5 GVFISAVLFLGTAQ----GASLGAVLTEGGMVQGKSRSVGLFRYMDTFKGIPFAAPP---KRFEK 62

  Fly    92 PEAVEPWDQELDCTSPADKPLQTHMFFRKYAGSEDCLYLNVYV-KDLQPDKLRPVMVWIYGGGYQ 155
            |.|...|:..|..|....:.||.::......|||||||||::| :........||||:||||.:.
Zfish    63 PVAHPGWEGVLKTTDYRKRCLQLNLLATDVIGSEDCLYLNIWVPQGRTVSSNLPVMVFIYGGAFL 127

  Fly   156 VGEASRDMYSPDFFMSKD-------VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRW 213
            :|......:..::....:       |::||..||:|||||:|..|.  .:|||.||.||..|:.|
Zfish   128 LGGGQGANFLDNYLYDGEEMADRGNVIVVTFNYRVGALGFMSTGDD--GIPGNYGLWDQHAAISW 190

  Fly   214 VQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPW--TQPPRNNWA 276
            |.:||:||||:.:||||||||||.||.:|..::|:.:|:|.:||..||..||||  ::.|| .:|
Zfish   191 VHRNIKAFGGNPDNITLFGESAGAASVNFQIITPKNKGMIRRAISQSGVALCPWAISRNPR-QFA 254

  Fly   277 YRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEK----HHRILFAFGPVVEPYTTE 337
            ..:|.|:|..   .|..:.:.|:......:..|....|::...    |:..|   .||:     :
Zfish   255 EEIATKVGCP---IDSGMADCLKRADPKAVTLAGKLKLTSSPDAPIVHNLYL---SPVI-----D 308

  Fly   338 HTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLF----YPEVSRRPAT--LDEVGNCKNLLPSDL 396
            ...:..:|..|..|:..  |..:.|....:..:|    .|.::....|  ::||......|..|.
Zfish   309 GDFIPDEPETLFGNAAD--IDYIAGVNDMDAHIFATIDIPSINNALTTTPVEEVQALATALSRDR 371

  Fly   397 GLNLDPKLRENYGLQLKKAY---FGDEPCNQANMMKFLELCSYREFWHPIYRAA-LNRVRQSSAP 457
            |        ::.|:...:.|   :||:|..:......:||.:...|..|...|. |:.....||.
Zfish   372 G--------QDAGIATFQEYTVNWGDKPNKEKVKQTVVELETDYMFLVPTQAALYLHTDNAKSAR 428

  Fly   458 TYLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDS--PEHKVITG-MVDV 519
            |:.|.|...|      ||.:....| |..|.|:|.|:|....   :.|..  |.|:.::. |:..
Zfish   429 TFSYLFTESS------RIPVFPLWM-GADHADELQYVFGKPF---ATPLGYFPRHRDVSKYMIAY 483

  Fly   520 WTSFAAHGDPN 530
            |::||..||||
Zfish   484 WSNFAQTGDPN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	156/509 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/156 (42%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	156/507 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740