DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and CG6414

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	177/492 - (35%)
Similarity:	250/492 - (50%)	Gaps:	62/492 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRK--YAGSEDCLYLNVYVK 135
            :|..:|:|:||:.||||:.|....||:.|......|...||...|.|.  ..|||||||||||.
  Fly    55 AFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMILEGSEDCLYLNVYT- 118

  Fly   136 DLQPDKLR-----PVMVWIYGGGYQVGEASRDMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQ 195
               |::.|     |||||.:|||:|.|......|.|||.:..|:|:|:..:|||.|||||.:  .
  Fly   119 ---PERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTE--T 178

  Fly   196 LNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMS 260
            |:.|||.|||||:..|.||:.||.:||||.|::|:|||||||||..:..||.::.||:|:.|..|
  Fly   179 LDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQS 243

  Fly   261 GSVLCPWTQPPRNNWAYRLAQKL------GYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEK 319
            |:...||.||.....|...|.||      |..|:..:|  .|.||.....:||.:...:...|
  Fly   244 GTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEK--LECLRKKPAEDIVASLYDMFVWD-- 304

  Fly   320 HHRILFAFGPVVEPYTTEH-----TVVAKQ---PHELMQNSWSHRIPMMFGGTSFEGLLFYPEVS 376
             ...:..|.|||||   ||     ||..:|   ||.|       ::|:|.|.|:.||||....:.
  Fly   305 -FDPMIPFPPVVEP---EHDGAFLTVAPRQAAKPHGL-------QLPLMVGATAEEGLLKTAALL 358

  Fly   377 RRPATLDEV-GNCKNLLPSDLGL-NLDPKLRENYGLQLKKAYF-GDEPCNQANMMKFLELCSYRE 438
            ..|..|.|. ...:.:||..|.. :.|..:|:....:::..|| .....::||.....:|.|  :
  Fly   359 NLPQLLAEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLIS--D 421

  Fly   439 FWHPIYRAALN---RVRQSS---APTYLYRFDHDSKLCNAIRIVLCG--HQMRGVCHGDDLCYIF 495
            .|   :.|.::   |:|.|.   ||||:|.|||  |...:...:..|  ::..|.||.::|.|:|
  Fly   422 GW---FVAGIDEYLRLRMSQEDVAPTYVYLFDH--KGAASFTEIFKGGRNEFYGACHAEELQYLF 481

  Fly   496 --HSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPN 530
              ...|...:.|...:.::...|:.:|.|||..|:||
  Fly   482 PIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPN 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	177/492 (36%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	71/151 (47%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	177/492 (36%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	69/143 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	6	5.810