DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	150/516 - (29%)
Similarity:	224/516 - (43%)	Gaps:	78/516 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TKSGPVRGVKRNTIWG--GSYFSFEKIPFAKPPVGDLRFKAPEAVEPWD-------------QEL 102
            |:.|.|:| |:.|:.|  .....|..||||.||:|.|||..|:...||.             |.|
  Rat    35 TRLGWVQG-KQATVLGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQNL 98

  Fly   103 DCTSPADKPLQTHMFFRKYAGSEDCLYLNVYVKDLQPDKLR-PVMVWIYGGGYQVGEASRDMYSP 166
            :........|:.|  :.|...||||||||:|......|..| |||:||.|||::.|.||  ::..
  Rat    99 EWLFIYQNLLKVH--YPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSAS--IFDG 159

  Fly   167 DFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITL 230
            ....: :||:|||:.||||..||.:..:.  :.|||...:||:.||:||::||..|||:.:::|:
  Rat   160 SALAAYEDVLIVTIQYRLGIFGFFNTQNQ--HAPGNWAFQDQLAALQWVRENINYFGGNPDSVTI 222

  Fly   231 FGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGD------N 289
            ||.|||..|...|.|||.:.||.|:||:.||..:.    |...|:...|...|....|      :
  Rat   223 FGGSAGAISISSLILSPLSAGLFHRAIMQSGVAII----PSLKNFDDELKHGLQVVADVCKCNVS 283

  Fly   290 KDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWS 354
            ..|.:.:.||.       |::..:||..:|..    ||..||     :.:...::|.||:.....
  Rat   284 DSKVLLKCLRE-------KSSLELLSLGQKTK----AFTRVV-----DGSFFPEEPMELLSQKTF 332

  Fly   355 HRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGD 419
            ..:|.:.|..:.|.....| :...|..|........|....:.|::.|:    |...:.|.||..
  Rat   333 KTVPSIIGVNNQECGYILP-MREAPEILFGSNESTALTLIHVLLHIPPQ----YMHIVAKDYFHG 392

  Fly   420 EPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRG 484
            :..........|:|.....|..|....|.|. |.:..|.|.|.|.|...         |....|.
  Rat   393 KHSLTDIRDTLLDLFGDVFFVVPGLVTARNH-RDAGGPVYFYEFQHRPN---------CFQNTRP 447

  Fly   485 VC----HGDDLCYIFHS-------MLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCESI 534
            ..    |.|::.::|..       ::..::..|  |..:...|:..|.:||..||||.:.:
  Rat   448 AFVKADHTDEIRFVFGGPFLEGDVVMFEEATED--EKLLSRKMMSYWANFARSGDPNGDDL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	150/516 (29%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	59/148 (40%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	148/511 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740