Protein Alignment alpha-Est10 and Nceh1

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001120996.1
• Gene: Nceh1 / 294930
• RGDID: 1311104
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 465
• Identity: 99/465 - (21%)
• Similarity: 158/465 - (33%)
• Gaps: 162/465 - (34%)

  Fly    92 PEAV-EPWD-QELDCTSPADKP---------LQTHM---------FFRKYAGSE----------D 126
            |.|| :||. ..||.|....:.         |..|:         |.:|.|.|.          |
  Rat    24 PSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLSHHLITLNFIIISFGKKSARSSPRVKVTDTDFD 88

  Fly   127 CLYLNVYVKDLQPDK-LRPVMVWIYGGGYQVGEASRDMYSP-DFFMSKDV--VIVTVAYRLGALG 187
            .:.:.|:....:||: ||..:|:|:|||:.:..|....|.. ...|::::  |||::.|||
  Rat    89 GVEVRVFEGPPKPDEPLRRSVVYIHGGGWALASAKISYYDQLCTAMAEELNAVIVSIEYRL---- 149

  Fly   188 FLSLDDPQLNVPGNAGLKDQIMALRWVQQN--IEAFGGDSNNITLFGESAGGASTHFLALSPQTE 250
                 .||:..|..  :.|.|.|.::..|.  ::.:..|...:.:.|:||||
  Rat   150 -----VPQVYFPEQ--IHDVIRATKYFLQPEVLDKYKVDPGRVGVSGDSAGG------------- 194

  Fly   251 GLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDK-----AIFEFLRSMSGGEIVKAT 310
                                   |.|..|.|:..|....|:|     .|:..|:::.
  Rat   195 -----------------------NLAAALGQQFTYVESLKNKLKLQALIYPVLQALD-------- 228

  Fly   311 ATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSF-EGLLFYPE 374
                .|...:.:.:..  |::             |..:|...|   :....|...| |.::....
  Rat   229 ----FNTPSYQQSMNT--PIL-------------PRHVMVRYW---VDYFKGNYDFVEAMIVNNH 271

  Fly   375 VS---RRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMK----FLE 432
            .|   .|.|.|....:..:||||.:..|..|.|:.          .||     |.::|    .|:
  Rat   272 TSLDVERAAALRARLDWTSLLPSSIKKNYKPVLQT----------IGD-----ARIVKEIPQLLD 321

  Fly   433 LCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHD----------SKLCNAIRIVLCGHQMRGVCH 487
            ..:     .|:  .|...|.|:...||:...:||          .:|.:|...|...|...|. |
  Rat   322 AAA-----SPL--IAEQEVLQALPKTYILTCEHDVLRDDGIMYAKRLESAGVNVTLDHFEDGF-H 378

  Fly   488 GDDLCYIFHS 497
            |   |.||.|
  Rat   379 G---CMIFTS 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	99/465 (21%)
Nceh1	NP_001120996.1	Abhydrolase_3	109..381	CDD:400284	75/374 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		0/1 (0%)