DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	177/578 - (30%)
Similarity:	248/578 - (42%)	Gaps:	118/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TKSGPVRG----VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ 113
            |.:|.|||    ||...   ....:|..|||||||||.|||..||..|||....|.||.....||
  Rat    36 THTGQVRGSFVHVKDTK---SGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQ 97

  Fly   114 THMF-----------FRKYAGSEDCLYLNVYVKDLQPDKLR-----PVMVWIYGGGYQVGEASRD 162
            |.:.           ......||||||||:|.    |...|     ||||||:|||..:|.||.:
  Rat    98 TDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYT----PAHAREGSNLPVMVWIHGGGLVLGSASMN 158

  Fly   163 MYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNN 227
            ..| ....::::|||::.||||.|||.|..|.  |..||.|..||:.|||||||||..|||:...
  Rat   159 DAS-TLAATEEIVIVSIQYRLGVLGFFSTGDQ--NARGNWGYLDQVAALRWVQQNIAYFGGNHGK 220

  Fly   228 ITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGD---N 289
            :|:||.||||.|.....:||.::||.|.||:.||..|.|                     |   :
  Rat   221 VTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLP---------------------DLISD 264

  Fly   290 KDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE--PYTTEHTVVAKQPHELMQNS 352
            |.:.:::.:.::||.|...:.|.:.....|..:.:.|...|.:  |...:...:.|.|.||:.:.
  Rat   265 KSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLPKHPQELLASG 329

  Fly   353 WSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLN--LDPKLRENYGLQLK-- 413
            ..|.:|.:.|                 ...||   |...:|..|||:  :....||.....||
  Rat   330 DFHPVPSIIG-----------------INTDE---CGWGIPVFLGLDHIIKKITRETLPTVLKST 374

  Fly   414 ---------------KAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRF 463
                           :.|.||....:....:|..:.....|..|..:.|  ..::|.||.|.|.|
  Rat   375 AAQMMLPPECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQVA--HFQRSQAPVYFYEF 437

  Fly   464 DHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMV-DVWTSFAAHG 527
            .|   |.:.|:.|...|....  ||||:.::|.|.|...:...:.|.:::...| ..|.:||..|
  Rat   438 QH---LPSFIKQVRPSHVKAD--HGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTG 497

  Fly   528 DPNCESIKSLKFAPIENVTNFKCLN----IGD-------QFEVMALPELQKIEPVWNS 574
            :||.|.:.  .:..:::...:..||    :|.       ||....||  |||:.:..|
  Rat   498 NPNGEDLP--HWPVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLP--QKIQELKGS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	166/533 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/151 (43%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	170/560 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840