DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	653	Identity:	177/653 - (27%)
Similarity:	254/653 - (38%)	Gaps:	165/653 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SLIPNKSVPK--VFTNGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVK---RNTIWG--GS 70
            ||.|..:|.:  ..|.| |:..|:      |..:.|....:.|..|.:||.:   .:.|.|  ..
Mouse     8 SLSPTPTVGRSLCLTLG-FLSLVL------RASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQ 65

  Fly    71 YFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PADKPLQTH---------MFFRK----- 120
            |..   :|:|.||:|:.||..||....|....:.|. |...|...|         ::|..
Mouse    66 YLG---VPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIV 127

  Fly   121 ----YAGSEDCLYLNVYV-----------------------KDLQPDKLRPVMVWIYGGGYQVGE 158
                ...:||||||||||                       :|::....:||||:|:||.|.  |
Mouse   128 ATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYM--E 190

  Fly   159 ASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFG 222
            .:.:|.......| .:|:::|:.||:|.|||||..|..  ..||.||.|||.|||||.:||..||
Mouse   191 GTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFG 253

  Fly   223 GDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWT---QPPRNNWAYRLAQKLG 284
            ||...||:||...|.:....|.||..:|||..:||:.|||.|..|.   ||.:  :...||.|:|
Mouse   254 GDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVK--YTSLLADKVG 316

  Fly   285 YTG-DNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHEL 348
            ... |..|  :.:.||..|..|:|:       .|.:..|...|||||:     :..|:...|..|
Mouse   317 CNVLDTVD--MVDCLRQKSAKELVE-------QDIQPARYHVAFGPVI-----DGDVIPDDPEIL 367

  Fly   349 MQNSWSHRIPMMFGGTSFEGLLFY-----PEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENY 408
            |:........:|.|....|||.|.     ||........|.  :..|.:.:..|.   |:.::..
Mouse   368 MEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDY--SVSNFVDNLYGY---PEGKDTL 427

  Fly   409 GLQLKKAY--FGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCN 471
            ...:|..|  :.|....:......:.|.:..::..|....|....|..| |||.|.|.|.
Mouse   428 RETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGS-PTYFYAFYHH----- 486

  Fly   472 AIRIVLCGHQMR----GVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDV------------- 519
                  |...|:    ...|||::.|:|       ..|       :.|..|:
Mouse   487 ------CQSLMKPAWSDAAHGDEVPYVF-------GVP-------MVGPTDLFPCNFSKNDVMLS 531

  Fly   520 ------WTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFYAP 578
                  ||:||..||||         .|:...|.| .....::||          |..|:.:...
Mouse   532 AVVMTYWTNFAKTGDPN---------KPVPQDTKF-IHTKANRFE----------EVAWSKYNPR 576

  Fly   579 NKL 581
            ::|
Mouse   577 DQL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	159/574 (28%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	64/173 (37%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	167/615 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740