DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	157/532 - (29%)
Similarity:	230/532 - (43%)	Gaps:	104/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFE----------KIPFAKPPVGDLRFKAPEAVEPWD----- 99
            |:.|..|.|.         |.|.|.|          .:||||||:|.|||..||..|||.
  Rat    27 VVDTTKGKVL---------GKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNT 82

  Fly   100 -----------------QELDCTSPADKPLQTHMFFRKYAGSEDCLYLNVY-VKDLQPDKLRPVM 146
                             .::..|...:.||:.         ||||||||:| ..||..:...|||
  Rat    83 TTYPPMCSQDGVVGKLLADMLSTGKENIPLEF---------SEDCLYLNIYSPADLTKNSRLPVM 138

  Fly   147 VWIYGGGYQVGEASRDMYSPDFFMS--KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIM 209
            |||:|||..:|.||  .|| ...:|  ::||:||:.||||..|..|..|....  ||....||:.
  Rat   139 VWIHGGGLIIGGAS--PYS-GLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR--GNWAHLDQLA 198

  Fly   210 ALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNN 274
            ||||||.||..|||:.:::|:|||||||.|...|.|||..:.|.|:||..||.||..........
  Rat   199 ALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKNTQ 263

  Fly   275 WAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHT 339
            ...::...|....:....|:.:.||..:..|:::.|.. |.|.        :...|:     :..
  Rat   264 AVAQMIATLSGCNNTSSAAMVQCLRQKTEAELLELTVK-LDNT--------SMSTVI-----DGV 314

  Fly   340 VVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDL------GL 398
            |:.|.|.|::.....:.:|.:.|....|.....|.:.   ..|...|.....:.|.|      .|
  Rat   315 VLPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMM---GNLLSEGRMNEKMASSLLRRFSPNL 376

  Fly   399 NLD----PKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNR-VRQSSAPT 458
            |:.    |.:.|.|   |:..   |:|..:    |.|.|..:.:.:..|....::| :|.:.|||
  Rat   377 NISESVIPAIIEKY---LRGT---DDPAKK----KELLLDMFSDVFFGIPAVLMSRSLRDAGAPT 431

  Fly   459 YLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMV-DVWTS 522
            |:|.|.:.....:..|    ...::| .|||::..:|.:....:.|  |.|...::.:| ..|.:
  Rat   432 YMYEFQYRPSFVSDQR----PQTVQG-DHGDEIFSVFGTPFLKEGA--SEEETNLSKLVMKFWAN 489

  Fly   523 FAAHGDPNCESI 534
            ||.:|:||.|.:
  Rat   490 FARNGNPNGEGL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	157/532 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/149 (44%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	157/532 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810