DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Cel

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	171/529 - (32%)
Similarity:	236/529 - (44%)	Gaps:	99/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AIYSVIKTKSGPVRGV--KRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPA 108
            |:|    |:.|.|.||  |.:.:.|.|...|:.||||....    .:.|:....|...|..|...
  Rat    25 AVY----TEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTLKATDFK 81

  Fly   109 DKPLQTHMFFRKYAGSEDCLYLNVYV----KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFF 169
            .:.||..:......|.|||||||::|    |.:..|  .|||||||||.:.:|......:..::.
  Rat    82 KRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHD--LPVMVWIYGGAFLMGSGQGANFLKNYL 144

  Fly   170 MSKD-------VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNN 227
            ...:       |::||..||:|.|||||..|  .|:|||.||:||.||:.||::||.|||||.:|
  Rat   145 YDGEEIATRGNVIVVTFNYRVGPLGFLSTGD--ANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDN 207

  Fly   228 ITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWT-QPPRNNWAYRLAQKLGYTGDNKD 291
            ||:||||||.||.....|||..:|||.:||..||..|.||. |.....||..:|:|:|...::..
  Rat   208 ITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTA 272

  Fly   292 KAIFEFLRSMSGGEIVKAT-------ATVLSNDEKHHRIL--FAFGPVVEPYTTEHTVVAKQPHE 347
            |        |:|  .:|.|       |..|....:.:.|:  .||.|||     :...:...|..
  Rat   273 K--------MAG--CLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVV-----DGDFIPDDPIN 322

  Fly   348 LMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENY---- 408
            |..|:..  |..:.|....:|.||        ||:|        :|:......|....:.|
  Rat   323 LYDNAAD--IDYLAGINDMDGHLF--------ATVD--------VPAIDKAKQDVTEEDFYRLVS 369

  Fly   409 ------GLQLKKAYF-------GDEPCNQANMMKFLELCSYRE---FWHPIYRA-ALNRVRQSSA 456
                  ||:..:|.|       ..:| :|.||.|  .:.::..   |..|...| |.:|....||
  Rat   370 GHTVAKGLKGTQATFDIYTESWAQDP-SQENMKK--TVVAFETDILFLIPTEMALAQHRAHAKSA 431

  Fly   457 PTYLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWT 521
            .||.|.|.|.|      |:.:....| |..|.|||.|:|....:......:.:..|...|:..||
  Rat   432 KTYSYLFSHPS------RMPIYPKWM-GADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWT 489

  Fly   522 SFAAHGDPN 530
            :||..||||
  Rat   490 NFAKSGDPN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	169/526 (32%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	71/158 (45%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	170/528 (32%)
		Aes	<118..>247	CDD:223730	63/130 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750