Protein Alignment alpha-Est10 and CES3

DIOPT Version :9

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 172/589 - (29%)
• Similarity: 258/589 - (43%)
• Gaps: 113/589 - (19%)

  Fly    40 QRKLSTAIYSVIKTKSGPVRGVKR--NTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQEL 102
            |.::.|.:..|...:.| |:|..|  |...|        ||||:||:|..||.||...:||:...
Human    33 QPEVDTTLGRVRGRQVG-VKGTDRLVNVFLG--------IPFAQPPLGPDRFSAPHPAQPWEGVR 88

  Fly   103 DCTSPADKPLQ------THMFF-----RKYAGSEDCLYLNVYVKDLQPDKL-----RPVMVWIYG 151
            |.::.....||      :..|.     :.::.|||||.||||    .|.::     ||||||::|
Human    89 DASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVY----SPAEVPAGSGRPVMVWVHG 149

  Fly   152 GGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQ 215
            |....|.|:  .|......: .|||:|||.||||.|||.|..|.  :.|||.|..|.:.||||||
Human   150 GALITGAAT--SYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDE--HAPGNQGFLDVVAALRWVQ 210

  Fly   216 QNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPW---TQPPRNNWAY 277
            :||..||||.|.:|:||.||||:....|.|||...||.|:||..||.:..|.   :.|    |.
Human   211 ENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHP----WP- 270

  Fly   278 RLAQKLGYT---GDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHT 339
             ||||:..|   ..:....:.:.|:...|.|:      |||...|:         .:.|.|.:.|
Human   271 -LAQKIANTLACSSSSPAEMVQCLQQKEGEEL------VLSKKLKN---------TIYPLTVDGT 319

  Fly   340 VVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLL----PSDLGLNL 400
            |..|.|.||::....|.:|.:.|..:.|.....|.......|::::.. :::|    |....|::
Human   320 VFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSR-EDMLAISTPVLTSLDV 383

  Fly   401 DPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIY----RAALNR-VRQSSAPTYL 460
            .|::...    :...|.|.....||....|      :||...::    ..:.:| :|.|.:|.:.
Human   384 PPEMMPT----VIDEYLGSNSDAQAKCQAF------QEFMGDVFINVPTVSFSRYLRDSGSPVFF 438

  Fly   461 YRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIF--------HSMLSHQSAPDSPEHKVITGMV 517
            |.|.|.......|:.......     ||.:..::|        .|.|:...|.:..:...:| |:
Human   439 YEFQHRPSSFAKIKPAWVKAD-----HGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLT-MM 497

  Fly   518 DVWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQF-EVMALPEL-QKIEPVWNSFYA--- 577
            ..||.||..||||.:::..           :...|..:|: |:..:|.. ||....|..|::
Human   498 AQWTHFARTGDPNSKALPP-----------WPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETL 551

  Fly   578 PNKL 581
            |:|:
Human   552 PSKI 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	160/534 (30%)
		Aes	<132..>279	CDD:223730	68/155 (44%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	169/579 (29%)
		Aes	<129..>247	CDD:223730	58/125 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3453
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820