Protein Alignment alpha-Est10 and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 172/617 - (27%)
• Similarity: 261/617 - (42%)
• Gaps: 148/617 - (23%)

  Fly    44 STAIYSVIKTKSGPVRGVKR---NTIWG--GSYFSFEKIPFAKPPVGDLRFKAPEAVEPW----- 98
            |.|.|.|:.|..|.::|::.   :.|.|  ..|..   :|:|.||.|:.||:.||:...|
Human    41 SQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLG---VPYASPPTGERRFQPPESPSSWTGIRN 102

  Fly    99 --------DQELD------------CTSPADKPLQTHMFFRKYAGSEDCLYLNVYV--------- 134
                    .|.||            .|:..| .|.|::    ...:|||||||:||
Human   103 ATQFSAVCPQHLDERFLLHDMLPIWFTTSLD-TLMTYV----QDQNEDCLYLNIYVPMEDGTNIK 162

  Fly   135 --------------KDL-QPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRL 183
                          ||: :.:..:||||:|:||.|.  |.:.:|.......| .:|:::|:.|||
Human   163 RNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYM--EGTGNMIDGSILASYGNVIVITINYRL 225

  Fly   184 GALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQ 248
            |.|||||..|..  ..||.||.|||.||||:::|:.|||||...:|:||..||.:....|.||..
Human   226 GILGFLSTGDQA--AKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHY 288

  Fly   249 TEGLIHKAIVMSGSVLCPWT---QPPRNNWAYRLAQKLGYTG-DNKDKAIFEFLRSMSGGEIVKA 309
            :|||..|||:.||:.|..|.   ||.:  :...||.|:|... |..|  :.|.|::.:..|:::.
Human   289 SEGLFQKAIIQSGTALSSWAVNYQPAK--YTRILADKVGCNMLDTTD--MVECLKNKNYKELIQQ 349

  Fly   310 TATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPE 374
            |.|..:    :|   .|||||:     :..|:...|..||:........:|.|....|||.|...
Human   350 TITPAT----YH---IAFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDG 402

  Fly   375 VSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGL---------QLKKAY--FGDEPCNQANMM 428
            :         |.|...:.|:|...::...:...||.         .:|..|  :.|:...:....
Human   403 I---------VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRK 458

  Fly   429 KFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMR----GVCHGD 489
            ..:.|.:..::..|.. |..:...|..:|||.|.|.|.           |..:|:    ...|||
Human   459 TLVALFTDHQWVAPAV-ATADLHAQYGSPTYFYAFYHH-----------CQSEMKPSWADSAHGD 511

  Fly   490 DLCYIFH-SMLSHQ---SAPDSPEHKVITGMV-DVWTSFAAHGDPNCESIKSLKFAPIENVTNFK 549
            ::.|:|. .|:...   |...|....:::.:| ..||:||..||||....:..||  |....|
Human   512 EVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF--IHTKPN-- 572

  Fly   550 CLNIGDQFEVMALPELQKIEPVWNSFYAPNKL 581
                  :||          |..|:.:...::|
Human   573 ------RFE----------EVAWSKYNPKDQL 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	162/571 (28%)
		Aes	<132..>279	CDD:223730	64/174 (37%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	169/612 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840