Protein Alignment alpha-Est10 and CES5A

DIOPT Version :10

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 160/544 - (29%)
• Similarity: 236/544 - (43%)
• Gaps: 113/544 - (20%)

  Fly    53 TKSGPVRGVKRNTIWGG--SYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT- 114
            |:.|.::| |:.|:.|.  ....|..:|||.||:|.|||..|:...|||...:.||..:..||.
Human    64 TRLGWIQG-KQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNS 127

  Fly   115 -------HMF---FRKYAGSEDCLYLNVYVKDLQP------DKLRPVMVWIYGGGYQVGEASRDM 163
                   ||.   :.|:..||||||||:|.    |      .|| ||:||..||.::.|.||  :
Human   128 EWLLLDQHMLKVHYPKFGVSEDCLYLNIYA----PAHADTGSKL-PVLVWFPGGAFKTGSAS--I 185

  Fly   164 YSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNN 227
            :......: :||::|.|.||||..||.:..|.  :.|||...|||:.||.|||:|||.||||.::
Human   186 FDGSALAAYEDVLVVVVQYRLGIFGFFTTWDQ--HAPGNWAFKDQVAALSWVQKNIEFFGGDPSS 248

  Fly   228 ITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDN--K 290
            :|:||||||..|...|.|||..:||.||||:.||..:.|:.:......:..|.....:.|:|  .
Human   249 VTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFCGNNASD 313

  Fly   291 DKAIFEFLRSMSGGEIVKATATVLSNDEKHHRIL-FAFGPVVEPYTTEHTVVAKQPHELMQNSWS 354
            .:|:...||:....|::    |:....:...|:: .||.|             .:|.:|:.....
Human   314 SEALLRCLRTKPSKELL----TLSQKTKSFTRVVDGAFFP-------------NEPLDLLSQKAF 361

  Fly   355 HRIPMMFGGTSFE-GLLF----YPEV---SRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQ 411
            ..||.:.|..:.| |.|.    .||:   |.:...|..:.|..::.|..|.|
Human   362 KAIPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYLHL------------- 413

  Fly   412 LKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIV 476
            :...||.|:..........|:|.....|..|....|... |.:.||.|.|.|.|
Human   414 VANEYFHDKHSLTEIRDSLLDLLGDVFFVVPALITARYH-RDAGAPVYFYEFRH----------- 466

  Fly   477 LCGHQMRGVC------------HGDDLCYIF------HSMLSHQSAPDSPEHKVIT-GMVDVWTS 522
                  |..|            |.|::.::|      ..::..:.|.:  |.|::: .|:..|.:
Human   467 ------RPQCFEDTKPAFVKADHADEVRFVFGGAFLKGDIVMFEGATE--EEKLLSRKMMKYWAT 523

  Fly   523 FAAHGDPNCESIKSLKFAPIENVT 546
            ||..|:||.   ..|...|..|:|
Human   524 FARTGNPNG---NDLSLWPAYNLT 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	156/529 (29%)
CES5A	NP_001177087.1	COesterase	58..568	CDD:395084	160/544 (29%)