DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est10 and Nlgn2

DIOPT Version :9

Sequence 1:NP_001246962.1 Gene:alpha-Est10 / 40896 FlyBaseID:FBgn0015569 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:597 Identity:184/597 - (30%)
Similarity:255/597 - (42%) Gaps:123/597 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 YSVIKTKSGPVRGVKR---NTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PA 108
            :.|:.|..|.||||:|   |.|. |....|..:|:|.||:|..||:.|||...|....:.|: |.
Mouse    41 FPVVNTAYGRVRGVRRELNNEIL-GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPP 104

  Fly   109 DKPLQTH---------MFF-------RKYA--GSEDCLYLNVYV--------------------K 135
            ..|...|         ::|       ..|.  .||||||||:||                    .
Mouse   105 ACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDT 169

  Fly   136 DLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVP 199
            |::....:|||::::||.|.  |.:.:|:......: .:|::||:.||||.|||||..|..  ..
Mouse   170 DIRDSGKKPVMLFLHGGSYM--EGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQA--AK 230

  Fly   200 GNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVL 264
            ||.||.|||.||||:.:||..||||...||:||..||.:..:.|.||..:|||..|||..||:.:
Mouse   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   265 CPWT---QPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFA 326
            ..|:   ||.:  :...||.|:|...::..:|: |.||..|..|:|       ..|.:..|...|
Mouse   296 SSWSVNYQPLK--YTRLLAAKVGCDREDSTEAV-ECLRRKSSRELV-------DQDVQPARYHIA 350

  Fly   327 FGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPE-------VSRRPATLDE 384
            |||||     :..||...|..|||........|:.|....|||.|..:       ||........
Mouse   351 FGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   385 VGNCKNLLPSDLGLNLDPKLRENYGLQLKKAY--FGDEPCNQANMMKFLELCSYREFWHP-IYRA 446
            .....||.....|.::   |||.    :|..|  :.|....:......|.|.:..::..| :..|
Mouse   411 SNFVDNLYGYPEGKDV---LRET----IKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATA 468

  Fly   447 ALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGH-QMRGVCHGDDLCYIFHSMLSHQSAPD---- 506
            .|:...||  |.|.|.|.|.   |.|.     |. :.....|||:|.|:|.  :....|.|    
Mouse   469 KLHADYQS--PVYFYTFYHH---CQAE-----GRPEWADAAHGDELPYVFG--VPMVGATDLFPC 521

  Fly   507 --SPEHKVITGMV-DVWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKI 568
              |....:::.:| ..||:||..||||....:..||  |....|        :||          
Mouse   522 NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF--IHTKPN--------RFE---------- 566

  Fly   569 EPVWNSFYAPNK 580
            |.||:.|.:..|
Mouse   567 EVVWSKFNSKEK 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est10NP_001246962.1 COesterase 49..542 CDD:278561 175/556 (31%)
Aes <132..>279 CDD:223730 61/170 (36%)
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 184/596 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832898
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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