DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	170/520 - (32%)
Similarity:	240/520 - (46%)	Gaps:	90/520 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TKSGPVRG----VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PAD--- 109
            |.:|.|||    ||...   ....:|..|||||||:|.|||..||..|||....|.|| ||.
  Rat    36 THTGQVRGSFVHVKDTK---SGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQ 97

  Fly   110 -------KPLQTHMFFRKYAGSEDCLYLNVYV-KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSP 166
                   :.|:..|.....:.|||||||::|. .....|...||||||:|||...|.||  .|..
  Rat    98 NIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMAS--TYDG 160

  Fly   167 DFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITL 230
            ....: :|||:||:.||||.|||.|..|.  :..||.|..||:.|||||||||..|||:.:.:|:
  Rat   161 SMLAAIEDVVVVTIQYRLGILGFFSTGDE--HARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTI 223

  Fly   231 FGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKAIF 295
            |||||||.|.....:||.::||.|.||:.||..|.|           .|.       .|..:.|:
  Rat   224 FGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLP-----------NLI-------SNTSEVIY 270

  Fly   296 EFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYT--TEHTVVAKQPHELMQNSWSHRIP 358
            ..:.::||.|.|.:.|.:....||....:.|...:|...:  .:...:.:.|.||:.:...|.:|
  Rat   271 TMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISGVVDGKFLPRHPLELLASVDFHPVP 335

  Fly   359 MMFGGTSFE-GL---LFYPEVSRRPATLDEVGN------CKN-----LLP---SDLGLNLDPKLR 405
            .:.|..|.| |.   :.:|:     :|:.|:..      .||     :||   |||
  Rat   336 SIIGINSDEYGWIIPMLHPD-----STMKEINRETMRAVLKNTAVQMMLPPECSDL--------- 386

  Fly   406 ENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLC 470
                  |.:.|.||...::...::|.|:.....|..|..:.|  ..::|.||.|.|.|.|.|
  Rat   387 ------LMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQVA--HFQRSHAPVYFYEFQHQS--- 440

  Fly   471 NAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHGDPNCESI 534
            |.::.:...|....  |||:|.|:...:........:.|.|::: .|:..|.:||.||:||.|.:
  Rat   441 NFLKDIRPPHVKAD--HGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEGL 503

Fly 535 534
Rat 504 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	170/520 (33%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	66/148 (45%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	170/520 (33%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	52/106 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740