DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and cest-30

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	152/569 - (26%)
Similarity:	235/569 - (41%)	Gaps:	138/569 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRG----VKRNTIWGGSYFSFEKIPFAKPPVGDL 87
            |.|:..:...|..|         ::....||:||    .|..|.....|..   |||||.|||.|
Worm    19 GGFLVNLTPEKNSQ---------ILNAPCGPIRGNIYKHKNGTKIVDGYLG---IPFAKAPVGAL 71

  Fly    88 RFKAPEAVEPWDQELDCTSPADKPLQTHMFFRKYAGS------EDCLYLNVYV---KDLQPDKLR 143
            :||.|.|.|.|.:..||........||..|....|.|      |:||.|||:.   |..:..|..
Worm    72 KFKKPVAAEKWTEPRDCYEYGPGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGL 136

  Fly   144 PVMVWIYGGGYQVGEASRDMYSPDFFMS-----KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAG 203
            ||:|:||||||::|..|   |..|:.::     |||::||:.||||.||||::.|...|  ||.|
Worm   137 PVLVYIYGGGYEIGFTS---YMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIAN--GNYG 196

  Fly   204 LKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWT 268
            |.||.:||:|||.||.:|||:..::||.|.|||..||.||:|||.:..|..::|.|||:..|.:.
Worm   197 LWDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFA 261

  Fly   269 QPPRN---NWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPV 330
            ..|::   ......||..||||.: .:::|::..:.:..:..:...
Worm   262 IRPKDVEVGVCKEFAQFQGYTGTD-SQSLFDWYMAQNVSKFKEVAG------------------- 306

  Fly   331 VEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYP---EVSRRPA----------TL 382
                              .|::.:..:|.:   .:|:| .|:|   ::.||.|          |:
Worm   307 ------------------FQSTAAGAVPFI---PNFDG-DFFPKPFDILRREAPKKDALITVVTM 349

  Fly   383 DEVG---------NCKNLLPSDLGLNLDPKLRENY--------GLQLKKAYFGDEPCNQANMMKF 430
            :.||         |..|.....:.....|.:.:.|        |..||.....|:......::.:
Worm   350 ESVGMIIFNPLFANAYNNFEGFINETYGPDVTDYYADVKKKLTGFYLKDVNASDKATVNRRVVDY 414

  Fly   431 LE-----------LCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRG 484
            :.           :.||.::.:.:|..:.|           |..|....:...::      ..:.
Worm   415 VSDSVFNSGTLDAVKSYVKYGNKVYLGSFN-----------YFNDATKDMVELMQ------PFKE 462

  Fly   485 VCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNCES 533
            ..|..|..|.|.|.:.....|...|.:|:.....:..:|..:||||.:|
Worm   463 ASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSGTLMANFVKYGDPNGKS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	148/547 (27%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	67/157 (43%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	149/557 (27%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	52/112 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740