DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and cest-19

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	165/569 - (28%)
Similarity:	249/569 - (43%)	Gaps:	118/569 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCT---------- 105
            ::..||.:|| :|....|..|..|:.||||.||||.|||:.|:....|...::.|
Worm    28 LRVNSGAIRG-ERLLTDGQDYSVFKGIPFAMPPVGYLRFQMPKEPAKWRGVMNATQYSAMCMQNI 91

  Fly   106 --SPADKPLQTHMFFRKYAG--SEDCLYLNV-------YVKDLQPDKLRPVMVWIYGGGYQVGEA 159
              :.|.:|       .:|..  |||||||||       |..|..     ||:|:|:||.:|.|..
Worm    92 DENDAGEP-------ERYVAHVSEDCLYLNVFSPTPYQYTNDTY-----PVIVFIHGGRFQTGSG 144

  Fly   160 S----RDMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEA 220
            |    |.:.|.  |:|:.:|.||..||||.|||.|..|..|  |||.||.|||.||:||:.|.|.
Worm   145 SDIPQRAILSN--FVSRKIVFVTFNYRLGPLGFASTGDSVL--PGNIGLWDQIWALKWVKANAEV 205

  Fly   221 FGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRN---NWAYRLAQK 282
            ||||.:||.|.|...|.||...|||||:.|||..|.::||||.|.|..  .||   |..:.:..:
Worm   206 FGGDPSNILLMGHGTGAASASLLALSPRAEGLFQKVLLMSGSALQPGV--VRNTQVNATWNMNDR 268

  Fly   283 LGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVV-EPYTTEHTVVAKQPH 346
            .|....|..: :.:..|..|..||.:.......:.|:...|:...|.:: ||           |.
Worm   269 FGCRAFNSSE-LLDCARKRSKEEIFQYKRLHFDDYEEFVPIIDGVGGILPEP-----------PE 321

  Fly   347 ELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDL----------GLNLD 401
            :|..:  ..:.|::.|.|.       .|.|.|...|:|    |:|..|.:          .|.|.
Worm   322 QLTLH--RRKTPIVIGTTK-------DESSLRILLLNE----KDLNFSSITWENGETLADNLTLG 373

  Fly   402 PKLRENY-----GLQLKKAYFGDEPCNQANMMKFLELCSYREFWH--PIYRAALNRVRQSSAPTY 459
            .|..:|:     |.:.:..:...:|....:::....|..|..||:  |..:.|...::. ..|.|
Worm   374 FKQFQNHRLISQGCKSEYVWTQVDPSFPESVLFNSLLKMYSHFWYDAPASQLATYYLKH-DLPVY 437

  Fly   460 LYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFH---SMLSHQSAPD-SPEHKVITGMVDVW 520
            ||.|||.|:..         :.:....||.|..:||:   ..|:.:...: ..:.:|:....::.
Worm   438 LYSFDHISENF---------YDIDRAFHGVDKLHIFNVTPRFLNKRKDMNWQLDQRVVEIFSELV 493

  Fly   521 TSFAAHGDPNCE-----------SIKSLKFAPIENVTNFKCLNIGDQFE 558
            .:||.:|.|..|           :.|.|.:.   ::|:...:.:|.:::
Worm   494 ANFALYGTPTHENDGFSFNWTSTTAKELSYL---SITDSPSMQVGYRWQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	163/551 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	72/160 (45%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	165/569 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810