DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and cest-33

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	162/523 - (30%)
Similarity:	249/523 - (47%)	Gaps:	93/523 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IKTKSGPVRG--VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ 113
            :|...|||||  .|.:.:....|..   ||:||||||:||||.|..|:.|.:..||.......:|
Worm    17 LKASCGPVRGNIYKHDDVIVDGYLG---IPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQ 78

  Fly   114 THMFFRKYAG-------SEDCLYLNVYVKDLQPDKL---RPVMVWIYGGGYQVGEASRDM--YSP 166
            |. .|.:.||       ...||.|||:.......:.   |||||:|:||||::. ||.|.  ||.
Worm    79 TG-GFEQIAGPRTPTPEEAGCLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELC-ASSDFCAYSL 141

  Fly   167 DFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNV-PGNAGLKDQIMALRWVQQNIEAFGGDSNNIT 229
            ...:. ||||:|::.||||..|||:..|   || |||.||.||.:||:|||::|.:||||.|.:|
Worm   142 SGTLPLKDVVVVSINYRLGVFGFLTTGD---NVCPGNFGLWDQTLALKWVQKHISSFGGDPNCVT 203

  Fly   230 LFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWA--YR-LAQKLGYTGDNKD 291
            :||:|||||||..|:|||.:..|..:.|.:||:..|.:......|.|  :| .|:..|::| ...
Worm   204 VFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQAKIFREFAEFHGFSG-RDS 267

  Fly   292 KAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHR 356
            .|:|::.:..|        ...|||.:.:.:.:..|...:.  ..:.....|...||.:.  :.:
Worm   268 SALFKWYQEQS--------PETLSNVKGYKKSISGFLTFIP--NLDGDFFPKPLDELRKE--APK 320

  Fly   357 IPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGL-------QLKK 414
            ..||.|.|.:|||:.   .|..||          ..|:|:||.|.|  :..||.       :::|
Worm   321 KQMMTGVTEYEGLML---ASMNPA----------FSPADVGLTLMP--QGIYGKDVVSNPDEIQK 370

  Fly   415 AYF-----GDEPCNQANMMKFLELCSY--REFWH-PIYRAALNRVRQSSAPTYLYRFDH------ 465
            .::     |.:..::..|.|  :||..  .||:: .:.:||.|..:..: ..|.|.|::
Worm   371 IFYEKYVEGVDKSDELAMRK--KLCEALGDEFFNVGVIQAAKNAAKHGN-EVYFYTFEYVNPDSF 432

  Fly   466 ---DSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHG 527
               |..:           ..:...|..:|.|:....:..:..|...:.||:.....::::||.:|
Worm   433 GMWDGMM-----------PFKAAVHCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYG 486

  Fly   528 DPN 530
            :||
Worm   487 NPN 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	162/523 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	71/156 (46%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	162/523 (31%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	63/124 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810