DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and cest-24

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	168/547 - (30%)
Similarity:	262/547 - (47%)	Gaps:	64/547 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIPNKSVPKVFTNGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTIWGGSYFSFEKIP 78
            |:|.|.. :|.|:.:  |..:...:...|...:..::::.:.|.:.|.:..|..|.....|..||
Worm    64 LLPIKKA-RVRTSSN--QSNMGTCFSNLKSGKSENAIVRVQQGLLEGFRVKTAKGDLCDVFHGIP 125

  Fly    79 FAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRKYA----GSEDCLYLNVYVKDLQP 139
            :|:||||:|||:.|:..:.|:....|....::.:...|.:.|..    .|||||||||:...::.
Worm   126 YAEPPVGELRFQKPQPPKAWEGIRKCNKYPNRSIHKEMPWDKALPSANQSEDCLYLNVFAPKIRE 190

  Fly   140 DKLRPVMVWIYGGGYQVGEASRDMYSP----DFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPG 200
            ||..||:.:|:||||.:..|.|  |:.    ...:|:::::||..||||.|||||..|..  .||
Worm   191 DKKYPVLFYIHGGGYVMDSAER--YTAKNICKLLVSREIIVVTFHYRLGFLGFLSTGDDV--CPG 251

  Fly   201 NAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLC 265
            |.||.|.:.|:|||..||.:||||..||||.|:|||.|:...|:.||.|:||..:.|||.|:..|
Worm   252 NYGLFDMLEAMRWVHANISSFGGDPENITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYC 316

  Fly   266 PWTQPPRNN-------WAYRLAQK--LGYTGDNKDKA-IFEFLRSMSGGEIVKATATVLSNDEKH 320
            .|.....::       ||.||..|  |.|....::.. ||.|   .:|....|...|:..::...
Worm   317 HWATTSNHDIREYCKKWAKRLGWKPQLNYANKREESVDIFNF---FNGLPTSKLGMTMFFSNTIF 378

  Fly   321 HRILFAFGPVVEPYTTEHTVVAKQPHEL--MQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLD 383
            ........||::....        ||:|  ::.:..| :|.:.||..:|.|||. .:.....|..
Worm   379 KECQLPLAPVIDGEIL--------PHDLKVLRETQEH-VPSLVGGGEYEALLFC-AIGLLRGTEK 433

  Fly   384 EVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPC----NQANMMKFLELCS--YREFWHP 442
            |:.:..::|.....|:     |.......:|.| ||.|.    ::|..|.|::|.|  :..:.:
Worm   434 EINSAIDVLSRKNRLS-----RSKIEAMTEKVY-GDSPALRADSKARKMFFVQLISDIFANYGN- 491

  Fly   443 IYRAALNRVRQSSAPTYLYRFDHDSK-LCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAP- 505
             || .:...:|.....|.|.|||.|| :...::.|:   ...|..|..:|.|:|.  .::.|||
Worm   492 -YR-FMRDCQQRGVECYGYSFDHQSKQMWGWLQHVV---PFTGGTHTSELSYLFD--CNYMSAPL 549

  Fly   506 -DSPEHKVITGM-VDVWTSFAAHGDPN 530
             .:...||::|| .|.:|:|...|.||
Worm   550 GMNKTDKVVSGMTADYFTNFVKFGTPN 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	161/512 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/157 (41%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	161/511 (32%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	47/105 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960