DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and cest-25

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	525	Identity:	154/525 - (29%)
Similarity:	236/525 - (44%)	Gaps:	92/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IKTKSGPVRGVKRNTIWGG--SYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ 113
            :.|..||:.|  |..|..|  ...:|:.||:|.||:|:|||..|:..|.|.:..:..|...:.:|
Worm    19 VLTSYGPIEG--RRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGIQ 81

  Fly   114 -THMFFRKYA-GSEDCLYLNVYVKDLQPDKLR--PVMVWIYGGGYQVGEASR--DMYSPDFFMSK 172
             .|:...|.: .|||.|.||::.....|....  ||:::|:|||:....|.:  ||......::|
Worm    82 KDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSICQHLVTK 146

  Fly   173 DVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGG 237
            |||:||:.||||.|||.:..|.  ::|.|..|.|.:.||:||::||..|.||.|||||.|:||||
Worm   147 DVVVVTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSAGG 209

  Fly   238 ASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRN-NWAYRLAQKLG-YTGDNKDKAIFEFLRS 300
            ||..||::||.:..|..|.|.|.|:..|.|...||. |.....||::| :.|.|....: |.||.
Worm   210 ASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWV-EKLRE 273

  Fly   301 MSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTS 365
            :...:...|......:.:....:|  .||..:.......|:..:....|:       |.:.|...
Worm   274 LPADKFASALNMEAVDTKTDPELL--IGPKYDNLFIPRPVMELRKEAPMK-------PRLLGCAK 329

  Fly   366 FEGLLF--------YP------EVSRRPATLDEVGNCKNLLP--------------SDLGLNLDP 402
            .|||:|        :|      :||   |.|.|     .|.|              .::|.:...
Worm   330 SEGLVFAFFGLNTKHPLHAVQQDVS---AILSE-----KLFPLKARDYQEKALEKLIEIGTDHSK 386

  Fly   403 KLRENYGLQLKKAYFGDEPCN---QANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFD 464
            :..:...:.||    ||...|   |.|::..||                   .|.|.|.|:|.||
Worm   387 EEWQRAMVDLK----GDSFLNVGIQQNVLDVLE-------------------TQPSTPIYMYSFD 428

  Fly   465 HDSKLCNAIRIVLCGHQM--RGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHG 527
            :    ||.....:.|.::  :...|..|:.|:..:.:.:....:..::|:|.....:||:||.:|
Worm   429 Y----CNPKAYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTNFAKYG 489

  Fly   528 DPNCE 532
            :||.|
Worm   490 NPNGE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	154/525 (29%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	63/151 (42%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	154/525 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820