DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and Cel

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	523	Identity:	163/523 - (31%)
Similarity:	229/523 - (43%)	Gaps:	87/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AIYSVIKTKSGPVRGV--KRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPA 108
            |:|    |:.|.|.||  |.:.:.|.|...|:.||||....    .:.|:....|...|..|:..
Mouse    25 AVY----TEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTLKATNFK 81

  Fly   109 DKPLQTHMFFRKYAGSEDCLYLNVYVKD--LQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS 171
            .:.||..:......|.|||||||::|..  .|.....|||||||||.:.:|......:..::...
Mouse    82 KRCLQATITQDNTYGQEDCLYLNIWVPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYD 146

  Fly   172 KD-------VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNIT 229
            .:       |::||..||:|.|||||..|  .|:|||.||:||.||:.||::||.|||||.:|||
Mouse   147 GEEIATRGNVIVVTFNYRVGPLGFLSTGD--ANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNIT 209

  Fly   230 LFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWT-QPPRNNWAYRLAQKLGYTGDNKDKA 293
            :||||||.||.....|||..:|||.:||..||..|.||. |.....||..:|:|:|...::..|
Mouse   210 IFGESAGAASVSLQTLSPYNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCPTEDTGK- 273

  Fly   294 IFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIP 358
            :...|:......:..|....:...|.......||.||:     :...:...|..|..|:..  |.
Mouse   274 MAACLKITDPRALTLAYKLPVKKQEYPVVHYLAFIPVI-----DGDFIPDDPINLYNNTAD--ID 331

  Fly   359 MMFGGTSFEGLLF----YPEVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENY----------- 408
            .:.|..:.:|.||    .|.|.:...|:.|                     |::
Mouse   332 YIAGINNMDGHLFATIDVPAVDKTKQTVTE---------------------EDFYRLVSGHTVAK 375

  Fly   409 GLQLKKAYF-------GDEPCNQANMMKFLELCSYRE---FWHPIYRA-ALNRVRQSSAPTYLYR 462
            ||:..:|.|       ..:| :|.||.|  .:.::..   |..|...| |.::....||.||.|.
Mouse   376 GLKGAQATFDIYTESWAQDP-SQENMKK--TVVAFETDVLFLIPTEIALAQHKAHAKSAKTYSYL 437

  Fly   463 FDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHG 527
            |.|.|      |:.:....| |..|.|||.|:|....:........:..|...|:..||:||..|
Mouse   438 FSHPS------RMPIYPKWM-GADHADDLQYVFGKPFATPLGYRPQDRAVSKAMIAYWTNFARSG 495

  Fly   528 DPN 530
            |||
Mouse   496 DPN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	161/520 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	70/156 (45%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	162/522 (31%)
		Aes	<117..>247	CDD:223730	63/131 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740