Protein Alignment alpha-Est10 and Nlgn2

DIOPT Version :9

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 597
• Identity: 183/597 - (30%)
• Similarity: 254/597 - (42%)
• Gaps: 123/597 - (20%)

  Fly    48 YSVIKTKSGPVRGVKR---NTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PA 108
            :.|:.|..|.||||:|   |.|. |....|..:|:|.||:|..||:.|||...|....:.|: |.
  Rat    41 FPVVNTAYGRVRGVRRELNNEIL-GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPP 104

  Fly   109 DKPLQTH---------MFF-------RKYA--GSEDCLYLNVYV--------------------K 135
            ..|...|         ::|       ..|.  .||||||||:||                    .
  Rat   105 ACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDT 169

  Fly   136 DLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVP 199
            |::....:|||::::||.|.  |.:.:|:......: .:|::.|:.||||.|||||..|..  ..
  Rat   170 DIRDSGKKPVMLFLHGGSYM--EGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA--AK 230

  Fly   200 GNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVL 264
            ||.||.|||.||||:.:||..||||...||:||..||.:..:.|.||..:|||..|||..||:.:
  Rat   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   265 CPWT---QPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFA 326
            ..|:   ||.:  :...||.|:|...::..:|: |.||..|..|:|       ..|.:..|...|
  Rat   296 SSWSVNYQPLK--YTRLLAAKVGCDREDSTEAV-ECLRRKSSRELV-------DQDVQPARYHIA 350

  Fly   327 FGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPE-------VSRRPATLDE 384
            |||||     :..||...|..|||........|:.|....|||.|..:       ||........
  Rat   351 FGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   385 VGNCKNLLPSDLGLNLDPKLRENYGLQLKKAY--FGDEPCNQANMMKFLELCSYREFWHP-IYRA 446
            .....||.....|.::   |||.    :|..|  :.|....:......|.|.:..::..| :..|
  Rat   411 SNFVDNLYGYPEGKDV---LRET----IKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATA 468

  Fly   447 ALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGH-QMRGVCHGDDLCYIFHSMLSHQSAPD---- 506
            .|:...||  |.|.|.|.|.   |.|.     |. :.....|||:|.|:|.  :....|.|
  Rat   469 KLHADYQS--PVYFYTFYHH---CQAE-----GRPEWADAAHGDELPYVFG--VPMVGATDLFPC 521

  Fly   507 --SPEHKVITGMV-DVWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKI 568
              |....:::.:| ..||:||..||||....:..||  |....|        :||
  Rat   522 NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF--IHTKPN--------RFE---------- 566

  Fly   569 EPVWNSFYAPNK 580
            |.||:.|.:..|
  Rat   567 EVVWSKFNSKEK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	174/556 (31%)
		Aes	<132..>279	CDD:223730	60/170 (35%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	183/596 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336481
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840