DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	525	Identity:	163/525 - (31%)
Similarity:	229/525 - (43%)	Gaps:	91/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SGPVRGVKRNTIWG---------GSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTS-PA- 108
            :.|:|...|..:.|         ....:|..|||||||||.|||..||..|||....|.|| ||
Mouse    30 ASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAM 94

  Fly   109 ---------DKPLQTHMFFRKYAGSEDCLYLNVYV-KDLQPDKLRPVMVWIYGGGYQVGEASRDM 163
                     :...:.::.....:.||||||||:|. ...|.....||||||:|||..||.||.:.
Mouse    95 CLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSASMND 159

  Fly   164 YSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNI 228
            .| ....::::|||.:.||||.|||.|..|.  :..||.|..||:.||||||:||..|||:.:.:
Mouse   160 VS-KLAATEEIVIVAIQYRLGVLGFFSTGDQ--HARGNWGYLDQVAALRWVQKNIAYFGGNRDRV 221

  Fly   229 TLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKA 293
            |:||.||||.|.....|||.::||.|.||:.||..|.|......:...|:....|........:|
Mouse   222 TIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVANLSGCEATDSEA 286

  Fly   294 IFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE--PYTTEHTVVAKQPHELMQNSWSHR 356
            :...||:.|..||:                  |...|.:  |...:...:.|.|.||:.:...|.
Mouse   287 LIHCLRAKSKQEIL------------------AINQVFKMIPAVVDGEFLPKHPQELLTSMDFHP 333

  Fly   357 IPMMFGGTS---------FEGL-LFYPEVSRR--PATLDEVG-------NCKNLLPSDLGLNLDP 402
            :|.:.|..:         |.|| .....::|.  ||.|....       .|.:||..:
Mouse   334 VPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEE------- 391

  Fly   403 KLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDS 467
                         |.||....:....:|.|:.....|..|..:.|  ..::|.||.|.|.|.|
Mouse   392 -------------YMGDTEDPETLQAQFREMLGDFMFVIPALQVA--HFQRSQAPVYFYEFQH-- 439

  Fly   468 KLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITG-MVDVWTSFAAHGDPNC 531
             |.:.|:.|...|....  ||||:.::|.|.|...:...:.|.:::.. |:..|.:||.:|:||.
Mouse   440 -LSSFIKHVRPSHVKAD--HGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNS 501

  Fly   532 ESIKS 536
            |.:.|
Mouse   502 EGLPS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	163/525 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/147 (44%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	163/525 (31%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	49/105 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750