DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces2

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	164/512 - (32%)
Similarity:	231/512 - (45%)	Gaps:	66/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KSGPVRGVKRNTIWG---------GSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPAD 109
            :|.|:|......:.|         ....:|..|||||||||.|||..||..|||....|.||...
  Rat    31 ESSPIRTTHTGQVQGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEPPEPWSGVRDATSQPA 95

  Fly   110 KPLQT------------HMFFRKYAGSEDCLYLNVYVKDLQPDKLR-----PVMVWIYGGGYQVG 157
            ..||.            .|.....:.||||||||||.    |...|     ||||||:||...||
  Rat    96 MCLQNLDILDEVGLLDMKMILSSISMSEDCLYLNVYA----PAHAREGSNLPVMVWIHGGALVVG 156

  Fly   158 EASRDMYSPDFF-MSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAF 221
            .||  ||..... :::|:|:||:.||||.|||.|..|.  :..||.|..||:.|||||||||..|
  Rat   157 MAS--MYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWVQQNIAHF 217

  Fly   222 GGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYT 286
            ||:.|.:|:|||||||.|.....:||.::||.|.||:.||..|.|......:........||...
  Rat   218 GGNPNRVTIFGESAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKLSGC 282

  Fly   287 GDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQN 351
            .....:|:...||:.||.||:     |::.       :|...|.|    .:...:.:.|.||:.:
  Rat   283 EAMDSEALVRCLRAKSGAEIL-----VINK-------VFKMIPAV----VDGEFLPRHPKELLAS 331

  Fly   352 SWSHRIPMMFGGTSFEGLLFYPEVSRRPATLDEVG--NCKNLLPSDLG-LNLDPKLRENYGLQLK 413
            ...|.:|.:.|..:.|.....|.|......:.|:.  |.:.:|..... :.|.|:.    |..|.
  Rat   332 EDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPEC----GDLLM 392

  Fly   414 KAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLC 478
            :.|.|:...:|...:::.|:.....|..|..:.|  ..::|.||.|.|.|.|.......:|   .
  Rat   393 EEYMGNTDDSQTLQIQYTEMMGDFLFVIPALQVA--HFQRSHAPVYFYEFQHAPSYFKNVR---P 452

  Fly   479 GHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHGDPNCESI 534
            .|....  |.|::.::|.|..|......:.|.:::: .|:..|.:||..|:||.|.:
  Rat   453 PHVKAD--HADEVPFVFGSFFSGMKLDFTEEERLLSRRMMKYWANFARQGNPNSEGL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	164/512 (32%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	69/152 (45%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	164/512 (32%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	55/110 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830