DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and bche

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	568	Identity:	171/568 - (30%)
Similarity:	264/568 - (46%)	Gaps:	86/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT 114
            ::.||.|.|.|| :.:::.|...:|..||:|:||:||||||.|...:||.:..:.:...:...||
Frog    32 IVDTKYGKVTGV-QISVFSGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYGNSCYQT 95

  Fly   115 -HMFFRKYAG----------SEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDF 168
             ...|..::|          ||||||||:::...:| :...||||||||.::.|.:|.|:|...|
Frog    96 VDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPTPKP-RNASVMVWIYGGSFETGTSSLDLYDGKF 159

  Fly   169 F-MSKDVVIVTVAYRLGALGFLSLDDPQLN-VPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLF 231
            . .::.|::|::.|||||||||:.  |..| .|||.||.||.:||:||.:||.||||:..:||:|
Frog   160 LARTERVIVVSMNYRLGALGFLAF--PGNNEAPGNVGLFDQRLALQWVYENIAAFGGNPKSITIF 222

  Fly   232 GESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPW---TQPPRNNWAYRLAQKLGYTGDNKDKA 293
            ||||||||..:..|||::.|...:||:.|.:...||   |:...:|.|..||..|.....|:.:
Frog   223 GESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANLLNCFYRNETE- 286

  Fly   294 IFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE---PYTTEHTVVAKQPHELMQ-NSWS 354
            |...||:.|..||.:...:||.     ||      .|:|   |.|.:...:.:.|..||| ....
Frog   287 IIACLRNKSPEEIFEKAVSVLP-----HR------SVIEVNFPPTVDGDFLIEMPEILMQLGQLK 340

  Fly   355 HRIPMMFGGTSFEGLLF----YPEVSR-RPATLDEV---GNCKNLLPSDLGLNLDPKLRENYGLQ 411
            .:..::.|....||..|    .|..|: ..:.::..   .:.|...|....|.:|..|
Frog   341 KKTQILTGVNKDEGSYFLVYGLPGFSKDHESFINRTQFHKSVKLAFPKATELAIDSVL------- 398

  Fly   412 LKKAYFGDE--PCNQANMM-----KFLELCSYREF--WHPIYRAALNRVRQSSAPTYLYRFDHDS 467
            .....:.||  |.:..:.|     .:..:|...||  |:          .:.....|||.|.|.|
Frog   399 FHYTNWEDEQNPSHNRDAMDDIVGDYNFICPLLEFTKWN----------SELGNNAYLYYFHHRS 453

  Fly   468 KLCNAIRIVLCGHQMRGVCHGDDLCYIF----HSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGD 528
            .     ::...|  ..||.||.::.::|    :..|::..|    |..:...::..|.:||..|:
Frog   454 S-----KLTWPG--WMGVMHGYEIEFVFGIPMYRRLNYTKA----EETLSRTLMRYWANFAKTGN 507

  Fly   529 PNCESIKSLKFAPIENVTNFKCLNIGDQFEVMALPELQKIEPVWNSFY 576
            ||.......:: |:..:.....|.:|.:..........|....||:||
Frog   508 PNGAQSSENRW-PVFTLDEQHYLMLGTEDSKTNRKMRAKQCRFWNNFY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	163/532 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	67/151 (44%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	167/562 (30%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910