DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and tg

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001316486.1	Gene:	tg / 100492021	XenbaseID:	XB-GENE-6073495	Length:	2780	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	136/570 - (23%)
Similarity:	221/570 - (38%)	Gaps:	104/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QRKLSTAIYSVIKTKSGPVRGVKRNTIWGG---SYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQE 101
            :||:.....:.:....|.:.|.....:.|.   :...|..||:|.||||..||..|:.|. |..|
Frog  2207 RRKVRPPPSTSVAIPQGTLLGKSEAVVIGSNIKNVVQFLGIPYAAPPVGVYRFSPPQPVN-WTGE 2270

  Fly   102 -------LDCTSPADKPLQTHMFFRKYAG-SEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGE 158
                   ..|..|.|...|       |:. .||||||||:|.. .......|:::.:.......|
Frog  2271 WNATYSRASCLQPGDGKAQ-------YSSVGEDCLYLNVFVPQ-HAGTNAAVLLYFHNSPSDYSE 2327

  Fly   159 ASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFG 222
            ..:......:..: .::|:||..||:|..|||| :..:....||.||.||:.||:|||:||..||
Frog  2328 KGQTFIDGSYLAAIGNIVVVTAGYRVGVFGFLS-NTGETAPSGNWGLLDQVAALKWVQENIAYFG 2391

  Fly   223 GDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPW---TQPPRNNWAYRLAQKLG 284
            ||...|::..:.||...:....:.|:.: |..:|::|.||...|.   ::.........||.::.
Frog  2392 GDPTLISIAADRAGADISSIHTIVPEGK-LFRRALLMGGSAFSPMMVTSEKRAKEQVEFLAAEVE 2455

  Fly   285 YTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELM 349
            .:..|||  :...||.:..|.:..|...:|:......    .:||:|:....:.|     |..::
Frog  2456 CSSSNKD--LLTCLRGVDAGALNAAQTKLLAQRGPFQ----TWGPIVDKLYVKET-----PSRML 2509

  Fly   350 QNSWSHRIPMMFGGTSFEGLLFYPEVSRR----PATLDEVGNCKNLLPSDLGLNLDPKLREN--- 407
            :.....:|.::.|.:..:||:...:..:|    ...:|:....:.|..|..|:..:..|:|.
Frog  2510 KQKKFQKIDLLIGSSELDGLISRAKAIKRFEETQGRVDKTAFYQALQNSLGGVEANSLLQEAAVW 2574

  Fly   408 -YGLQLKKAYFGDEPCNQANMMKFLELCSYREFWH-PIYRAALNRVRQSSAPTYLYRFDHDSKLC 470
             |.|:    :..|:   .....|.||..:...|.. |:.:.|.:....|....|||
Frog  2575 FYSLE----HSSDD---YTGFSKALEKATRDHFIACPVIKMAKHWAENSKGNIYLY--------- 2623

  Fly   471 NAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPNC---- 531
                            |..|      ::....|..|.||        ||..:|......|.
Frog  2624 ----------------HVPD------TLSQSSSGLDLPE--------DVIRAFGLPFHTNYKNQF 2658

  Fly   532 ---ESIKSLKFAPIENVTNFKCLNIGD-QFEVMALPELQKIEPVWNSFYA 577
               |.|.|||.  ::.|:||  :..|: .|....|..:.|..|.|..:.|
Frog  2659 SSEEQILSLKI--MQYVSNF--VRTGNPNFPYKFLRRISKELPAWPMYLA 2704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	124/523 (24%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	41/150 (27%)
tg	NP_001316486.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000