DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and ache

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	520	Identity:	161/520 - (30%)
Similarity:	238/520 - (45%)	Gaps:	81/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT 114
            ::.|:||.|||: |..:......:|..||||:|||..:||:..|..:||....|.|:   .|...
Frog    30 LVSTRSGKVRGL-RQPVLSTHVSAFLGIPFAEPPVDKMRFRRSEPKKPWTDVWDATA---YPNAC 90

  Fly   115 HMFF-RKYAG-------------SEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYS 165
            :.:| ..|.|             ||||||||::|...:|.. ..|||||||||:..|.:|.|:|.
Frog    91 YQYFDTLYPGFPGMEMWNPNRPMSEDCLYLNIWVPHPRPSN-ATVMVWIYGGGFYSGSSSLDVYD 154

  Fly   166 PDFFM-SKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNIT 229
            ..:.. :::|::|::.||:||.|||:|....::.|||.||.||.:||:|||.||..||||...:|
Frog   155 GRYLCHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRLALQWVQDNIAFFGGDPRTVT 219

  Fly   230 LFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPW-TQPPRNNWAYRLAQKLGYTGD---NK 290
            :||||||..|.....|||.:..|..||.:.|||...|| |..|:.  |.|..:.||...|   ..
Frog   220 IFGESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITPQE--ARRRTELLGKFLDCRMGN 282

  Fly   291 DKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE----PYTTEHTVVAKQPHELMQN 351
            |..:...||.....|::....:||.......   |||.||.:    |          :|.|::.|
Frog   283 DTELLNCLRVKQPQELIDHEFSVLPAPSVFR---FAFVPVPDADFFP----------EPPEILMN 334

  Fly   352 SWSHR-IPMMFGGTSFEGLLFY----PEVSRRPATL----DEVGNCKNLLPSDLGLNLDPKLR-- 405
            ....: .|::.|....||..|.    |..|:...:|    :.:|..|..:|....:.|:..:.
Frog   335 MGRFKPCPLIMGVNQNEGSYFLLYGAPGFSKNNESLITREEFLGGVKMSVPQANDIALEAVVMQY 399

  Fly   406 -----ENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDH 465
                 |:.|::.::|.  |:.....|:     :|....|        ..:|.::....|.|.|||
Frog   400 TDWADEHAGVKNREAM--DQLVGDHNV-----ICPLTYF--------AGKVAETGNRVYTYFFDH 449

  Fly   466 DSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPN 530
              :..|     |...|..||.||.::.::|...|.........|..:...|:..|.:||..||||
Frog   450 --RASN-----LAWPQWMGVPHGYEIEFVFGLPLDANLNYTPQEEALSRRMMRYWANFARTGDPN 507

Fly 531 530
Frog 508 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	161/520 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	65/148 (44%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	161/519 (31%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910