DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and ces3.1

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001120019.1	Gene:	ces3.1 / 100144981	XenbaseID:	XB-GENE-6467140	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	168/538 - (31%)
Similarity:	249/538 - (46%)	Gaps:	84/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 FEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ--------THMFFRKY---AGSEDC 127
            |..:||||||:|.|||:||:..|||....:.|:|:...||        ...|..|:   ..||||
Frog    51 FMGVPFAKPPIGPLRFEAPQPPEPWSSVREATAPSPMCLQDKEVMELLADFFKAKFDFSRVSEDC 115

  Fly   128 LYLNVYV-KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLS 190
            |||||:. .|...:...||||:|:|||..:|.||  |:......: ::||:|::.||||.:||||
Frog   116 LYLNVFTPADKGENPGLPVMVFIHGGGLAIGGAS--MFEGSALSAYENVVVVSIQYRLGIMGFLS 178

  Fly   191 LDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHK 255
            ..|.:  |.||.|..||:.||:||:.||:.||||..::|:|||||||.|...|.|||.:|||.|:
Frog   179 TGDKE--VRGNFGFLDQVAALQWVRDNIKDFGGDPQSVTIFGESAGGLSVSALVLSPLSEGLFHR 241

  Fly   256 AIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKH 320
            ||..||..:.|.....:......|...:..........:...|::.:..||::.||
Frog   242 AIAESGVAILPGLTASKTEEILPLLDMVINVSSCSVSDLVGCLKNKTEDEIIEITA--------- 297

  Fly   321 HRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFE-GLLFYPEVSRRPATLDE 384
                 |...|:.|...:...:.|...|::....||.:|.:.|..:.| |       |..|.||:.
Frog   298 -----AMRYVIFPAVVDGVFLPKPAEEILAAKESHPVPFLIGINNHEFG-------SMLPVTLNI 350

  Fly   385 VGNCKNLLPSDLG--LNLDPKLRENYGL--QLKKAYFGD--EPCNQANMMKFLELCSYREFWHPI 443
            .|..:.:...|:.  |...|.|.....:  .:.:.||||  :|....|  .||:|.....|..|.
Frog   351 TGYREGMEKKDIQAILGALPLLNTVSSVIPFIMEEYFGDTNDPKELRN--NFLDLAGDIIFVIPA 413

  Fly   444 YRAALNRVRQSSAPTYLYRFDH------DSKLCNAIRIVLCGHQMRGVCHGDDLCYI------FH 496
            .|.|... |.|..|.|.|.|.|      |||           .......|||:|.::      .:
Frog   414 LRTAKYH-RDSGFPVYFYEFQHRPSLYADSK-----------EDFVKADHGDELYFVGGGPFLKN 466

  Fly   497 SMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHGDPNCESIKSL-KFAPIE-----NVTNFKCLNI- 553
            .:|...:..:  |.|::: .::..|.:||.:||||...:... |:...|     |:|......:
Frog   467 GILFKSNGTE--EEKILSKTIMKYWANFARNGDPNGHGLAEWPKYDEDEDYLEINLTQKSSQRLK 529

  Fly   554 GDQFE--VMALPE-LQKI 568
            |::||  .:.||: :||:
Frog   530 GERFEFWTITLPDKIQKL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	158/501 (32%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	64/148 (43%)
ces3.1	NP_001120019.1	COesterase	25..536	CDD:365897	164/525 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910