DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	164/570 - (28%)
Similarity:	237/570 - (41%)	Gaps:	137/570 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ISFKYEQRKLSTAIYS------VIKTKSGPVRGVKRNTIWGGSYFSFE----------KIPFAKP 82
            :||.:.....:..:|.      |:.|..|.|.         |.|.|.|          .:|||||
  Rat     3 LSFLFLVSLATCVVYGNPSSPPVVDTTKGKVL---------GKYVSLEGVTQSVAVFLGVPFAKP 58

  Fly    83 PVGDLRFKAPEAVEPWDQELD-------CTSPADK-----PLQT------HMFFRKYAGSEDCLY 129
            |:|.|||..|:..|||....:       |:..|.|     .|.|      |:.|     ||||||
  Rat    59 PLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEF-----SEDCLY 118

  Fly   130 LNVYV-KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLD 192
            ||:|. .|...:...||||||:|||..:|.||  .|......: ::||:|.:.||||..||.|..
  Rat   119 LNIYTPADFTKNSRLPVMVWIHGGGMTLGGAS--TYDGRVLSAYENVVVVAIQYRLGIWGFFSTG 181

  Fly   193 DPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAI 257
            |....  ||.|..||:.||.|||.||..||||..::|:|||||||.|...|.|||.|:.|.|:||
  Rat   182 DEHSR--GNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAI 244

  Fly   258 VMSGSVLCP--WTQPPRNNWAYRLAQKLGYTGDN--------KDKAIFEFLRSMSGGEIVKATAT 312
            ..||.|..|  .|:..|.. |.::|...|.....        :.|...|.|..|....::|.::.
  Rat   245 SESGVVFLPGLLTKDVRPA-AKQIADMAGCETTTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQ 308

  Fly   313 VLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFE-GLLFYPEVS 376
             ..|.|.:|.:    ..||     ::.|:.|.|.|::.....:.:|.:.|....| |.|....:.
  Rat   309 -RDNKESYHFL----STVV-----DNVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMG 363

  Fly   377 RRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGL----------QLKK-------------AYFG 418
            ..||.::        |...:.:.|..|....||:          :.:|             |:.|
  Rat   364 FVPADVE--------LDKKMAITLLEKFASLYGIPEDIIPVAIEKYRKGSDDSIKIRDGILAFIG 420

  Fly   419 DEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIR---IVLCGH 480
            |...:..::|...:        |          |.:.||||:|.:.:.....:..|   :|  |.
  Rat   421 DVSFSIPSVMVSRD--------H----------RDAGAPTYMYEYQYYPSFSSPQRPKHVV--GD 465

  Fly   481 QMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPN 530
                  |.|||..:|.:.:....|.:. |.|:...::..|.:||.:|:||
  Rat   466 ------HADDLYSVFGAPILRDGASEE-EIKLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	161/555 (29%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	67/150 (45%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	161/549 (29%)
		Aes	<121..>234	CDD:223730	53/116 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm44890
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740