DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est10 and Ces1f

DIOPT Version :10

Sequence 1:NP_001246962.1 Gene:alpha-Est10 / 40896 FlyBaseID:FBgn0015569 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_001096829.2 Gene:Ces1f / 100125372 RGDID:1642419 Length:561 Species:Rattus norvegicus


Alignment Length:570 Identity:164/570 - (28%)
Similarity:237/570 - (41%) Gaps:137/570 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 ISFKYEQRKLSTAIYS------VIKTKSGPVRGVKRNTIWGGSYFSFE----------KIPFAKP 82
            :||.:.....:..:|.      |:.|..|.|.         |.|.|.|          .:|||||
  Rat     3 LSFLFLVSLATCVVYGNPSSPPVVDTTKGKVL---------GKYVSLEGVTQSVAVFLGVPFAKP 58

  Fly    83 PVGDLRFKAPEAVEPWDQELD-------CTSPADK-----PLQT------HMFFRKYAGSEDCLY 129
            |:|.|||..|:..|||....:       |:..|.|     .|.|      |:.|     ||||||
  Rat    59 PLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEF-----SEDCLY 118

  Fly   130 LNVYV-KDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLD 192
            ||:|. .|...:...||||||:|||..:|.||  .|......: ::||:|.:.||||..||.|..
  Rat   119 LNIYTPADFTKNSRLPVMVWIHGGGMTLGGAS--TYDGRVLSAYENVVVVAIQYRLGIWGFFSTG 181

  Fly   193 DPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAI 257
            |....  ||.|..||:.||.|||.||..||||..::|:|||||||.|...|.|||.|:.|.|:||
  Rat   182 DEHSR--GNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAI 244

  Fly   258 VMSGSVLCP--WTQPPRNNWAYRLAQKLGYTGDN--------KDKAIFEFLRSMSGGEIVKATAT 312
            ..||.|..|  .|:..|.. |.::|...|.....        :.|...|.|..|....::|.::.
  Rat   245 SESGVVFLPGLLTKDVRPA-AKQIADMAGCETTTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQ 308

  Fly   313 VLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFE-GLLFYPEVS 376
             ..|.|.:|.:    ..||     ::.|:.|.|.|::.....:.:|.:.|....| |.|....:.
  Rat   309 -RDNKESYHFL----STVV-----DNVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMG 363

  Fly   377 RRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGL----------QLKK-------------AYFG 418
            ..||.::        |...:.:.|..|....||:          :.:|             |:.|
  Rat   364 FVPADVE--------LDKKMAITLLEKFASLYGIPEDIIPVAIEKYRKGSDDSIKIRDGILAFIG 420

  Fly   419 DEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIR---IVLCGH 480
            |...:..::|...:        |          |.:.||||:|.:.:.....:..|   :|  |.
  Rat   421 DVSFSIPSVMVSRD--------H----------RDAGAPTYMYEYQYYPSFSSPQRPKHVV--GD 465

  Fly   481 QMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFAAHGDPN 530
                  |.|||..:|.:.:....|.:. |.|:...::..|.:||.:|:||
  Rat   466 ------HADDLYSVFGAPILRDGASEE-EIKLSKMVMKFWANFARNGNPN 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est10NP_001246962.1 COesterase 49..533 CDD:395084 161/555 (29%)
Ces1fNP_001096829.2 COesterase 22..545 CDD:395084 161/551 (29%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 558..561
Blue background indicates that the domain is not in the aligned region.

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