DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wa-cup and CG15128

DIOPT Version :9

Sequence 1:	NP_649721.2	Gene:	wa-cup / 40892	FlyBaseID:	FBgn0037502	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_611441.1	Gene:	CG15128 / 37263	FlyBaseID:	FBgn0034467	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	212/567 - (37%)
Similarity:	311/567 - (54%)	Gaps:	33/567 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LQAPIAGVQPHLQPWEAHAWSPDRLGSMYSDWAMFFFTQQRYANGLRYFNSALDLNPFNERALMR 75
            ::.|.|.::..|.||....||.:.|..:|.||..::..::|....|.|.|.||.|.|.:...|.:
  Fly     5 VEMPRANLEEALPPWMKIDWSDEVLHDIYRDWGTYYSRRRRENFALHYLNKALALEPTDHMTLYK 69

  Fly    76 RSQLKRSMGLASEALKDCSRAEDLLMSRKPPVTNPNVSLEVCDALYESNRLEDSKINLHCHL--- 137
            |.|.||.......||.| |||...|...|.......::|::||.|||.|:.|:||..:|.::
  Fly    70 RCQSKRKAAQMLGALDD-SRAAAKLARSKDGEEKAIINLDICDVLYELNQFENSKAEMHNNMRVF 133

  Fly   138 ---KRFSSGQRGPVLDRLNVLNENFHDTLS-----DDTTMSV--------QRLINRMMASLAKEP 186
               ||.|..||..|:|  .|:.:...:.:|     :..|:|:        :|:.||.:....||
  Fly   134 IGNKRKSFEQRQLVVD--GVIKDVTGEAMSAFFTKNLKTVSIVHDLIKERERVDNRPLWKRLKE- 195

  Fly   187 KDIKDTCDVVSIMENEETHLSPLEMARRKRHFKIYNQTYLNKCWVDVAFLKTLRDDPNVLPKHCK 251
               :..|||.||.|..|..|||:|:|||||.|.|::|:|:|..|:||.|:|.|..:||:|...||
  Fly   196 ---QGKCDVQSIPEVPEEMLSPMEIARRKRAFNIFHQSYINDSWIDVLFMKMLCKNPNLLLPQCK 257

  Fly   252 KSSEYLGKLMASNYKAERTLTKTLHTRSPMYALHQQKYPNEAFYNKHREENLYRIQYQTRRNMFK 316
            :||.:|.:|.:..|:..|...|.|.:|||:|.::..||.|:|..:|:||..|:|:||||.|||..
  Fly   258 ESSYFLQQLSSKQYEIVRKFMKMLQSRSPLYLVNYLKYGNKAMSDKYREAYLFRVQYQTHRNMNH 322

  Fly   317 ILRSIRLLIRVGELNKLTTFIEEVMGDYVTIKTNRVMPWKFEFTNEVYNYLGLARINEYKIPSNM 381
            .|:.||.|.:..::.:|..|:||:||.||.:||.|||.|||||.|||||.:.|....:.::|...
  Fly   323 ALKEIRALRKAKKVQQLAKFVEELMGTYVVLKTARVMCWKFEFLNEVYNTMALTLAEQLRVPKGF 387

  Fly   382 TVLQGKQRLLTLFRLPLSNSLDMKKSKTKRTSALNITRSATTDPKAEHFKKQVVRLENRMRFAEY 446
            |. .|...:|.|.|||:....|.    ...|...........||.....|:...|||:||.||:|
  Fly   388 TP-YGSNAILKLLRLPVERVKDF----VPVTFGDRAPEPEGNDPATTRAKRLTARLEHRMVFAKY 447

  Fly   447 HIERAYLLHELAQEHLNCNSFDGACSMARMALEEAIKCKSVIWSFLSLMVICKAHAILGKIEREK 511
            .||:.||||:::|.:|:..........||.|::|:..|.|.:|.|||::.|.||:|||.|:|:.|
  Fly   448 SIEKCYLLHQISQSYLDQGRHSECTYNARKAIKESKNCNSNLWKFLSVVQIVKANAILHKLEQTK 512

  Fly   512 EILAEAFELAKKMKNLDLCLFIDICIKVNAEEMEMKRMVTTDLTAKR 558
            |.|.:|..:|..:|:.:|.|||:.|:..|.|:...||  .|.:.|:|
  Fly   513 EALEDALPIAHFLKSSELILFIENCMACNTEDSINKR--ATLMQARR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wa-cup	NP_649721.2	TPR_11	39..99	CDD:290150	22/59 (37%)
		TPR repeat	39..64	CDD:276809	8/24 (33%)
		TPR repeat	69..99	CDD:276809	11/29 (38%)
CG15128	NP_611441.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450493
Domainoid	1	1.000	152	1.000	Domainoid score	I8865
eggNOG	1	0.900	-	-		E1_2BEUU
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I6773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009964
OrthoInspector	1	1.000	-	-		otm50006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21391
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7635
	9	8.890