DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wa-cup and r-cup

DIOPT Version :9

Sequence 1:	NP_649721.2	Gene:	wa-cup / 40892	FlyBaseID:	FBgn0037502	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_608419.1	Gene:	r-cup / 33075	FlyBaseID:	FBgn0031142	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	210/576 - (36%)
Similarity:	312/576 - (54%)	Gaps:	61/576 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 APIAGVQPHLQPWEAHAWSPDRLGSMYSDWAMFFFTQQRYANGLRYFNSALDLNPFNE-RALMRR 76
            ||...:..:|:.||...|..::...:|..|..:|...::.....:||:..:..|...: :||..|
  Fly     8 APAGLLVANLKSWETFDWPTEQQRWIYRSWGQYFARMRKNTFAQKYFDKCITENESTDHKALYLR 72

  Fly    77 SQLKRSMGLASEALKDCSRAEDLLMSRKPPVTNPNVSLEVCDALYESNRLEDSKINLHCHLKRFS 141
            |:.|||:.|..:||:|..||.::..:     .:.|||:|:.||||:.||.|::|..||.:::|.:
  Fly    73 SKFKRSVALTQDALEDSLRAMEVRQA-----WDANVSMELGDALYDLNRFEENKSLLHDNVRRHA 132

  Fly   142 SGQRGPVLDRLNVLNENFHDTLSDDTTMS----------------------VQRLINRMMASLAK 184
            ........:||.|::||    |.|.|..|                      ::|...|.:..:.|
  Fly   133 GTALKSFENRLVVVDEN----LKDCTGFSLANFFMEHSAQLPGFYAHQQEELRRADRRPLWKILK 193

  Fly   185 EPKDIKDTCDVVSIMENEETHLSPLEMARRKRHFKIYNQTYLNKCWVDVAFLKTLRDDPNVLPKH 249
            |.|:    |||.|.::.:|..|||||..||:|..||:.|.||.:.|.|..||||||..||.|..:
  Fly   194 ERKE----CDVQSRIDRKEVMLSPLERERRRRKTKIFYQNYLGRSWTDFFFLKTLRRHPNCLLDN 254

  Fly   250 CKKSSEYLGKLMASNYKAERTLTKTLHTRSPMYALHQQKYPN-EAFYNKHREENLYRIQYQTRRN 313
            ...||....|.:...::..:|.|:.|..|.|||..:..:.|. ||   :.|:.||:|||||||||
  Fly   255 HFGSSADRTKYLEYAFQRLKTFTRMLQARRPMYKEYFHRNPQIEA---RMRDANLFRIQYQTRRN 316

  Fly   314 MFKILRSIRLLIRVGELNKLTTFIEEVMGDYVTIKTNRVMPWKFEFTNEVYNYLGLARINEYKIP 378
            |..|||:|::|....::.:|..|:|||||.||.|||||:||||.||.|||||.|.|:....|::|
  Fly   317 MVSILRTIKVLRGRNDIKRLRKFVEEVMGSYVVIKTNRLMPWKAEFMNEVYNNLALSLCEGYRLP 381

  Fly   379 SNMTVLQGKQRLLTLFRLPLSNSLDMKKSKTKRTSALNITRSA---------TTDPKAEHFKKQV 434
            ........|..:..|..:|::..|:       .|..:...||.         :||..|:  :.|:
  Fly   382 PTRVTPYDKSAMCQLLNIPVAKPLE-------HTELIFGDRSTYSYAGADKQSTDRLAD--QNQI 437

  Fly   435 VRLENRMRFAEYHIERAYLLHELAQEHLNCNSFDGACSMARMALEEAIKCKSVIWSFLSLMVICK 499
            ..||.|:.||...|||:|||||||..|:..|.|..:.|.|:.|:|||..|.|:||.|||.|::.|
  Fly   438 EYLEKRLLFARLPIERSYLLHELADRHMQKNHFVQSLSYAQKAIEEARVCNSLIWEFLSTMLMAK 502

  Fly   500 AHAILGKIEREKEILAEAFELAKKMKNLDLCLFIDICIKVNAEEMEMKRM---VTT 552
            :||:|.|.||:.|:|..|:|||.::|:..||.||::|..:|.:.:.:::|   |||
  Fly   503 SHAVLHKYERQTEVLNSAYELAAQLKSPQLCTFIELCRMLNKDYITLRKMSQLVTT 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wa-cup	NP_649721.2	TPR_11	39..99	CDD:290150	19/60 (32%)
		TPR repeat	39..64	CDD:276809	5/24 (21%)
		TPR repeat	69..99	CDD:276809	13/30 (43%)
r-cup	NP_608419.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450491
Domainoid	1	1.000	152	1.000	Domainoid score	I8865
eggNOG	1	0.900	-	-		E1_2BEUU
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I6773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009964
OrthoInspector	1	1.000	-	-		otm50006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21391
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7635
	9	8.890