DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	792	Identity:	154/792 - (19%)
Similarity:	278/792 - (35%)	Gaps:	263/792 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLQVKVISW--PL-IILTAFLRVLQIESINTNFLELAAFEDFLRSEHLSHVLVVRGDDADGDWKI 64
            |.:|.|||.  |: :.|:.:..::|  :.:.:..|:.....||.....:.|.:|. :|.| ||:.
plant   126 KARVPVISLNSPMSLSLSKYTHLIQ--ATHNSASEVKGITAFLHGFDWNSVALVL-EDHD-DWRE 186

  Fly    65 ECH-------------QKLLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFG 116
            ..|             |..:| :.|......:.....:|...|   |.|.|::...|:..| :|.
plant   187 SMHFMVDHFHENNVHVQSKVA-FSVTSSEDSLMDRLRELKDLG---TTVFVVHLSEVIATR-LFP 246

  Fly   117 VASEAGYFNNSLAWFILGSG----------------------------------------RESLP 141
            .|.:.|......||.:....                                        |::||
plant   247 CAEKLGMMGEGFAWILTSRSMSSFHDQFIDDLTKEAMEGVVGFKSYIPMSKELHNFTLRWRKTLP 311

  Fly   142 VEQL----IDQL-LSG-------YRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKK 194
            ||::    |.:| :||       :.:...|::|   |.|...|.|. :..:.||         .|
plant   312 VEEVTGSEITRLSISGVWAHDVAWSLASAAEVT---RMPTVTSTLL-EAIKESR---------FK 363

  Fly   195 GLWTHSGGYQ---------KF-------------------GNFKNTWVIRRRNFLNV-----TLI 226
            ||   ||.:|         ||                   |:|.|     ||...:.     |:|
plant   364 GL---SGNFQLDDMKLLSDKFEIVNMIGSGERRVGFWNSNGSFSN-----RRQLSSTHDNLETII 420

  Fly   227 GSTVLTEKPPGFGDMEYLADDKQLQQL---------------DPMQRK-------TYQLFQLVER 269
            ......:.|.|....|  :..|:|:.|               ||:..:       ..::||....
plant   421 WPGGSAQSPKGRSLRE--SGRKKLRVLVTSSNRFPRLMKVETDPITHEITIVEGFCIEVFQASIA 483

  Fly   270 MFNLSLAISLTDKWGELLDNGSWSGVMGQVTSR--EADFAVCPIRFVLDRQPYVQYSAVLHTQNI 332
            .||..:...   :|   |:..:::.:...:.|:  :.|.||..|....||..||.::.......:
plant   484 PFNYEVEYI---RW---LNGTNYTKLAYALHSQKDKYDAAVGDITITSDRSMYVDFTLPYTEMGL 542

  Fly   333 HFLFRHPRRSHIKNIFFEPLSNQVWWCVLA--LVTGSTILLLFHVRLERMLSNMENRFSF----- 390
            ..:....|...   :||:||:..:|....|  ::||..:.|     :|| ..|.|.:.|:
plant   543 GIVAAKERSMW---VFFQPLTPNLWITSAAFFVLTGIIVWL-----IER-AENKEFQGSWPQQIG 598

  Fly   391 --VWF---TMLETY---LQQGPANEIFRLFSTRLLI-------SLSCIFSFMLMQF-----YGAF 435
              :||   |::..:   ||...:..:..::...:||       :|:.:.:...::|     |...
plant   599 VVIWFGFSTLVYAHREKLQHNLSRFVVTVWVFAVLILVTSYTATLTSMMTVQQIRFNANEDYVGH 663

  Fly   436 IVGSLLSESARSIVNLQAL--------YDSNLAIGMENISYNFPIFTNTSNQLVRDV-YVKKICK 491
            :.|||::.:|.:..:|:|:        .|...|:..:::||           :|.:: |:|.:.
plant   664 LSGSLIANAALTNSSLRAMRLLGLNTSEDYAQALMNKSVSY-----------IVSELPYLKILL- 716

  Fly   492 SGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPYDSGSVMPKG 556
             ||:             .|.|           |:::.|.....|              |.:..||
plant   717 -GEN-------------PGHF-----------LMVKTQSTTNGF--------------GFMFQKG 742

  Fly   557 SPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPALFALALAMVASAL 621
            |....:::..:...|.:..|...:::|..::...:...||. .:.|..|. .||.:.....|.||
plant   743 SELAPNVSREIAKLRTSERLNEMERRWFDKQLPYTTDDTSN-PITLYRFR-GLFMITGVSFAFAL 805

  Fly   622 VFLLELFL--HW 631
            ..||.|:|  .|
plant   806 AVLLILWLRERW 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	14/70 (20%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	76/425 (18%)
		Lig_chan	355..602	CDD:278489	49/282 (17%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	61/310 (20%)
		ANF_receptor	55..387	CDD:279440	58/285 (20%)
		GluR_Plant	440..770	CDD:270404	71/395 (18%)
		Lig_chan	563..801	CDD:278489	53/296 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100