DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and GLR2.8

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	711	Identity:	148/711 - (20%)
Similarity:	255/711 - (35%)	Gaps:	212/711 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ELAAFED---FLRSEHLSHVL--VVRG---DDADGDWKIECH---QKLLANYRVQFYRPEMSANF 87
            |:...|:   :|.:..::|::  :..|   :..||...:..|   .|.|.::|:::.|     ||
plant   242 EIGMMEEGYVWLMTNGMTHMMRHIHHGRSLNTIDGVLGVRSHVPKSKGLEDFRLRWKR-----NF 301

  Fly    88 --------EDLMFYG---SPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGSGRESLP 141
                    :||..:|   ...|..|.:..|...:....:..||  |..||...   ||:...|..
plant   302 KKENPWLRDDLSIFGLWAYDSTTALAMAVEKTNISSFPYNNAS--GSSNNMTD---LGTLHVSRY 361

  Fly   142 VEQLIDQLLSGYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPL--II-----EKK--GLW 197
            ...|: :.||..|..       .|.|..|.         |.||..:|.  ||     |::  |.|
plant   362 GPSLL-EALSEIRFN-------GLAGRFNL---------IDRQLESPKFEIINFVGNEERIVGFW 409

  Fly   198 THSGGY-------------QKFGNF----KNT-----WVIR------------RRNFLNVTLIGS 228
            |.|.|.             ::||..    |:|     |.|.            ::.|.|...:.:
plant   410 TPSNGLVNVNSNKTTSFTGERFGPLIWPGKSTIVPKGWEIPTNGKKIKVGVPVKKGFFNFVEVIT 474

  Fly   229 TVLTE--KPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGEL---LD 288
            ..:|.  .|.|:....:.|..|:|.            :.::.:.:...   |..|.:.:|   :|
plant   475 DPITNITTPKGYAIDIFEAALKKLP------------YSVIPQYYRFE---SPDDDYDDLVYKVD 524

  Fly   289 NGSWSGVMGQVT-----SREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKN-- 346
            ||:...|:|.||     |..|||.:          ||.:....:...        .|.:..||
plant   525 NGTLDAVVGDVTITAYRSLYADFTL----------PYTESGVSMMVP--------VRDNENKNTW 571

  Fly   347 IFFEPLSNQVW---WCVLALVTGSTILLLFHVRLERMLSNMENR----------FSFVWFTMLET 398
            :|.:|....:|   .|...|:  ..::.||..|:     |.:.|          |.|.:.||:..
plant   572 VFLKPWGLDLWVTTACFFVLI--GFVVWLFEHRV-----NTDFRGPPHHQIGTSFWFSFSTMVFA 629

  Fly   399 YLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESAR-SIVNLQALYDSNLAIG 462
            :.::..:|      ..|.::.:.|....:|.|.|.|.:...|..:..: :.:|::.|..:...:|
plant   630 HREKVVSN------LARFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQPAAINVKDLIKNGDYVG 688

  Fly   463 MENISYNFPIFTNTSNQLVRDVYVKK---ICK-----SGEHNIMSLQQGAERIIQGRFAFHTAID 519
            .::.::            |:|..:|:   :.|     |.|.....|..|:........|:..||.
plant   689 YQHGAF------------VKDFLIKEGFNVSKLKPFGSSEECHALLSNGSISAAFDEVAYLRAIL 741

  Fly   520 RMY---RLLLELQMDEAEFCDLQEVMFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDK 581
            ..|   ..::|.....|.|              |...|:.||....::.|:|:......:|:.:.
plant   742 SQYCSKYAIVEPTFKTAGF--------------GFAFPRNSPLTGDVSKAILNVTQGDEMQHIEN 792

  Fly   582 KWMVRRPDCSLFKT--SQAEVDLEHFAPALFALALAMVASALVFLLELFL------HWLPD 634
            ||.:::.||...||  |...:.|..|. .||  .:|.:||.|..|:.:||      |.|.|
plant   793 KWFMKQNDCPDPKTALSSNRLSLRSFW-GLF--LIAGIASFLALLIFVFLFLYENRHTLCD 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	16/74 (22%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	73/397 (18%)
		Lig_chan	355..602	CDD:278489	52/273 (19%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	47/203 (23%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	75/412 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100