DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and GLR2.2

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	655	Identity:	124/655 - (18%)
Similarity:	220/655 - (33%)	Gaps:	203/655 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KLLANYRVQFYR--PEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWF 131
            |.|..:|.::.|  |:|..|...|..|.:  |..|.:..|             :||.  |::.:.
plant   288 KDLETFRSRWKRRFPQMELNVYGLWAYDA--TTALAMAIE-------------DAGI--NNMTFS 335

  Fly   132 ILGSGR-----ESLPVEQLIDQLLSGYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLII 191
            .:.:|:     :.|.:.|...:||....       ||..:|      |..|.:.:|.|.. |.:.
plant   336 NVDTGKNVSELDGLGLSQFGPKLLQTVS-------TVQFKG------LAGDFHFVSGQLQ-PSVF 386

  Fly   192 E----------KKGLWTHSGGYQK--------FGNFKNTWVIRRRNFL------------NVTLI 226
            |          ..|.||...|..|        .|.. :||....::.:            .:...
plant   387 EIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIGTL-STWPDHLKHIIWPGEAVSVPKGWEIPTN 450

  Fly   227 GSTVLTEKPP--GFGDMEYLADDKQLQQLDPMQRKT------YQLFQ-LVERM-FNLSLAISLTD 281
            |..:....|.  ||.|:..:.       .||:...|      ...|: :::.| :::|......:
plant   451 GKKLRIGVPKRIGFTDLVKVT-------RDPITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFPFE 508

  Fly   282 KWGELLDNGSWSG----VMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRS 342
            |     .||..:|    ::.||...:.|..|.....:.:|..:|.::.......:..:.  |.:.
plant   509 K-----PNGEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIV--PLKD 566

  Fly   343 HIKN---IFFEPLSNQVWWCVLA--LVTGSTILLLFHVRLERMLSNMENRFSFVWFTMLETYLQQ 402
            .:|.   .|.:|||.::|...|.  .:.|.::..|.|    |:.|:.                 :
plant   567 EVKRDKFSFLKPLSIELWLTTLVFFFLVGISVWTLEH----RVNSDF-----------------R 610

  Fly   403 GPAN----EIFRL-FSTRLLISLSCIFSF--------------MLMQFYGAFIVGSLLSESAR-S 447
            ||||    .||.. |||.:......:.||              :|.|.|.|.:...|.|:... :
plant   611 GPANYQASTIFWFAFSTMVFAPRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQQLNPT 675

  Fly   448 IVNLQALYDSNLAIGMENISY--------NFP----IFTNTSNQLVRDVYVKKICKSGEHNIMSL 500
            |.::.:|......:|.:..|:        .||    :..:|:.:.  |..:||..|:|......|
plant   676 ITSMSSLLHRGETVGYQRTSFILGKLNETGFPQSSLVPFDTAEEC--DELLKKGPKNGGVAAAFL 738

  Fly   501 QQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPYDSGSVMPKGSPWREHLAH 565
            .....|:..|::.      ..|:::              |..||:. ..|.|.|.|||....::.
plant   739 GTPYVRLFLGQYC------NTYKMV--------------EEPFNVD-GFGFVFPIGSPLVADVSR 782

  Fly   566 ALLHFRATGLLQYNDKKWM----------VRRPDCSLFKTSQAEVDLEHFAPALFALALAMVASA 620
            |:|....:......:..|.          |..||.:               |.:.|:.|.:.:..
plant   783 AILKVAESPKAVELEHAWFKKKEQSCPDPVTNPDSN---------------PTVTAIQLGVGSFW 832

  Fly   621 LVFLL 625
            .:||:
plant   833 FLFLV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	12/44 (27%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	78/411 (19%)
		Lig_chan	355..602	CDD:278489	55/290 (19%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	34/154 (22%)
		ANF_receptor	47..392	CDD:279440	29/134 (22%)
		HisJ	438..>587	CDD:223904	28/162 (17%)
		GluR_Plant	452..801	CDD:270404	77/406 (19%)
		Lig_chan	582..819	CDD:278489	55/295 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100