DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and grik1b

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	523	Identity:	127/523 - (24%)
Similarity:	205/523 - (39%)	Gaps:	83/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QLIDQLLSGYRMGIDADITVALRGPDNASML----FYDVYRISRQANTPLIIEKKGLWTHSGGYQ 204
            |:|.....|.|...|.|| ::|:.......|    |..|::            |.|:|..:.|..
Zfish   402 QIIINKTDGLRKDFDLDI-ISLKEDGLEKPLESGRFNKVWK------------KIGVWNSNTGLN 453

  Fly   205 --KFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLV 267
              .....|||.|  ..:..|.|||.:|:| |.|    .:.|...||.|...|..:.....|.:.:
Zfish   454 LTDSNKDKNTNV--TDSMANRTLIVTTIL-ENP----YVMYKKSDKPLYGNDRFEGYCLDLLKEL 511

  Fly   268 ERMFNLSLAISL-TD-KWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQ 330
            ..:...|..:.| || |:|...|.|.|:|::.::....||.||.|:.....|:..:.:|....|.
Zfish   512 SNILGFSYEVKLVTDGKYGAQNDKGEWNGMVRELIDHVADLAVAPLTITYVREKVIDFSKPFMTL 576

  Fly   331 NIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERM-----------LSN 383
            .|..|:..|..::.... |..|||..:|..||....|.:.:|....|....           ...
Zfish   577 GISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDV 641

  Fly   384 MENRFSF---VWFTMLETYLQQGPANEIF-RLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSES 444
            :||.|:.   |||. :...:|||  :|:. :..|||::..:...|:.:::..|.|.:...|..|.
Zfish   642 VENNFTLINSVWFG-VGALMQQG--SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 703

  Fly   445 ARSIVNLQALYDS--NLAIGMENISYNFPIFTNTSNQLVRD----VYVKKICKSGEHNI---MSL 500
            ..|.:      ||  :|| ....|.|.          .|||    .:.||...|....:   ||.
Zfish   704 MDSPI------DSADDLA-KQTKIEYG----------AVRDGSTMTFFKKSKISTYEKMWAFMSS 751

  Fly   501 QQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQEV---MFNLPYDSGSVMPKGSPW 559
            ::....:...|......:...|.||:|   ::......|:|.::   :.:..|..|:  |.|||:
Zfish   752 RKNTALVKNNREGIQRVLTTDYALLMESTSIEYISQRNCNLTQIGGLIDSKGYGVGT--PIGSPY 814

  Fly   560 REHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-VDLEHFAPALFALALAMVASALVF 623
            |:.:..|:|..:..|.|....:||. |...|....:.:|. :.:|:.......||..:|.|..|.
Zfish   815 RDKVTIAILQLQEEGKLHMMKEKWW-RGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVA 878

  Fly   624 LLE 626
            :.|
Zfish   879 IGE 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	96/393 (24%)
		Lig_chan	355..602	CDD:278489	62/277 (22%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	15/65 (23%)
		ANF_receptor	80..423	CDD:279440	7/21 (33%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	98/396 (25%)
		Lig_chan	602..871	CDD:278489	65/291 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840