DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir84a and Gria1

DIOPT Version :9

Sequence 1:NP_649720.2 Gene:Ir84a / 40891 FlyBaseID:FBgn0037501 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:713 Identity:154/713 - (21%)
Similarity:268/713 - (37%) Gaps:188/713 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MIKLQVKVISWPLIILTAFLRVLQIE-------SINTNFLELAAFEDFL---------RSEHLSH 49
            ::||:...|.:..|:  |.|..:.|:       ..|....:|..:.|.:         .|:...|
  Rat   216 IVKLEKNGIGYHYIL--ANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDH 278

  Fly    50 VLVVRGDDADGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYGSPRT--AVLVLNSEHVLVRR 112
            ..|        |||                ||:          |.|..|  .|.|:......:||
  Rat   279 TRV--------DWK----------------RPK----------YTSALTYDGVKVMAEAFQSLRR 309

  Fly   113 QVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM-GIDADITVALRGPDNAS 172
            |...::  ..||  ..|.::.|   |.|   :.:::.:.|:    |. |:..::....:|     
  Rat   310 QRIDISRRGNAGDCLANPAVPW---GQG---IDIQRALQQV----RFEGLTGNVQFNEKG----- 359

  Fly   173 MLFYDVYRISRQANTPL-IIEKK-------GLWTHSGGY-------QKFGNFKNTWVIRRRNFLN 222
                      |:.|..| :||.|       |.|.....:       |..|:  |:.|..|     
  Rat   360 ----------RRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQNR----- 407

  Fly   223 VTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM-----FNLSLAISLTDK 282
             |.|.:|:| |.|       |:...|...|.:...|......:|...:     ::..|.|....|
  Rat   408 -TYIVTTIL-EDP-------YVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGK 463

  Fly   283 WGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKN 346
            :|.. .|..:|:|::|::....||.||.|:...|.|:..:.:|....:..|..:.:.|::|....
  Rat   464 YGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 528

  Fly   347 I-FFEPLSNQVWWCVLALVTGSTILLL--------------FHVRLERMLSNMENRFSF---VWF 393
            . |.:||:.::|.|::....|.:::|.              |....::..|:..|.|..   :||
  Rat   529 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWF 593

  Fly   394 TMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQAL 454
            : |..::|||    |     |..|.|::..:...|:.:::..|.|.:...|..|  |.:..:::.
  Rat   594 S-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE--RMVSPIESA 650

  Fly   455 YD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM--SLQQGAERI--IQGR 511
            .|    :.:|.|..........|..:...:...::.  ..||.|.::.  :.::|..|:  .:|:
  Rat   651 EDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWT--YMKSAEPSVFVRTTEEGMIRVRKSKGK 713

  Fly   512 FAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLH 569
            :|:          |||..|:|    .:.||..:|..||  ||   |...||||..|..:..|:|.
  Rat   714 YAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIATPKGSALRNPVNLAVLK 766

  Fly   570 FRATGLLQYNDKKWMVRRPDC------SLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE 626
            ....|||.....||...:.:|      |..|||  .:.|.:.|...:.|...:..:.||.|:|
  Rat   767 LNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS--ALSLSNVAGVFYILIGGLGLAMLVALIE 827

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir84aNP_649720.2 nt_trans <54..>112 CDD:294020 10/59 (17%)
Periplasmic_Binding_Protein_Type_2 222..583 CDD:304360 91/403 (23%)
Lig_chan 355..602 CDD:278489 65/288 (23%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 44/236 (19%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 94/416 (23%)
Glutamate binding. /evidence=ECO:0000250 492..494 1/1 (100%)