DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and grin2da

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	720	Identity:	133/720 - (18%)
Similarity:	238/720 - (33%)	Gaps:	214/720 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FEDLM----------FYGSPRTAVLVLN---------------SEHVLVR---------RQVFGV 117
            :||.:          |.|..|.:|::||               .....||         .|:|..
Zfish   228 YEDFLAMVEGMIDGSFIGWERKSVVMLNLTDDPGGARTRRLLKENEAQVRLLYCSQEEAEQIFKA 292

  Fly   118 ASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLS----GYRMGIDADITVALRGPDNASMLFYDV 178
            |..:|....|..||.:|.|...|.:|.|...|.:    |:|   |.......:|   .|:|.:..
Zfish   293 AWASGQATPSHMWFAVGPGLSGLGLEGLPKALFAVRPQGWR---DEPRRRIAKG---VSVLTHGA 351

  Fly   179 YRISRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEY 243
            ..:.|:..     ..:|. :.:|.....||.......|.|.|.|:||.|      :...|.:..|
Zfish   352 MALRREYG-----GARGT-SFAGNCMMDGNQTQRVPGRIRFFSNITLSG------RDYSFNNDGY 404

  Fly   244 LA-------------------------------------------DDKQLQQLDPMQRKTYQLFQ 265
            ||                                           ||.|..::..::.:.:.:.:
Zfish   405 LANPLLDVISYTAGRGWEEVGWWENGVLRLRYPPWSRYGPFLKPLDDSQHLRVVTLEERPFVIVE 469

  Fly   266 ------------------------------------------LVERM-----FNLSLAISLTDKW 283
                                                      :::|:     |...|.:....:.
Zfish   470 PADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTNGRH 534

  Fly   284 GELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIF 348
            |:.:| |.|:|::|:|.|:.||.|:..:....:|...|::|.......|..:......:...:.|
Zfish   535 GKNID-GQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGISVMVSRSNGTVSPSAF 598

  Fly   349 FEPLSNQVW--WCVLALVTGSTILLLFH----VRLERMLSNME----NRFSF---VWFTMLETYL 400
            .||.|..||  ..|:.|...:..:.:|.    |...|.|.:.:    ::|:.   :|......:.
Zfish   599 LEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGYNRSLQSGKTAGGSKFTIGKSIWLLWALVFN 663

  Fly   401 QQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSN------- 458
            ...|. |..|..::::::.:...|:.:.:..|.|.:...::.|  ..|..:..|.|..
Zfish   664 NSVPV-ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE--EYIDTVSGLSDKKFQHPTEQ 725

  Fly   459 ---LAIGM-------ENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERIIQGR-- 511
               |..|.       |||..|:|   |....:||            :|...::...|.:..|:
Zfish   726 YPPLRFGTVPNGSTEENIRSNYP---NMHQYMVR------------NNQRGVEDAIENLKTGKLD 775

  Fly   512 -FAFHTAIDRMYRLLLELQMDEAEFCDLQ-----EVMFNLPYDSGSVMPKGSPWREHLAHALLHF 570
             |.:..|:       |.....:.|.|.:.     :|.....|  |..:.|.|.|:..|..|||..
Zfish   776 AFIYDAAV-------LNYMARKDEGCKVMTIGSGKVFATTGY--GVALHKNSRWKRPLDLALLQL 831

  Fly   571 RATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPALFALALAMVASALVFLLELFLHWLPDF 635
            .....:...::.|:.........:...:::|:::.|...:.|.:||..|.|||..|..::|  ..
Zfish   832 VGDDEIDMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYW--KL 894

  Fly   636 RRRLG 640
            |..||
Zfish   895 RHCLG 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	10/58 (17%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	81/488 (17%)
		Lig_chan	355..602	CDD:278489	49/284 (17%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	45/230 (20%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	72/426 (17%)
		HisJ	<507..>590	CDD:223904	18/83 (22%)
		Lig_chan	605..877	CDD:278489	52/298 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930