DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and CG11155

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	164/696 - (23%)
Similarity:	284/696 - (40%)	Gaps:	141/696 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PLIILTAFLRVLQIES-------INTNF-LELAAFEDFLRSEHLSHVLVVRGDDADGDWKIECHQ 68
            |..|.:.|..:||::.       :.|.| ||....|||..:.  .::...|..|.|....:|...
  Fly   230 PSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNS--VNITAFRLVDVDSKRYLEVIN 292

  Fly    69 KLLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFN--NSLAWF 131
            ::          .::..|..|.: .|||     .:.:|..|:...|:..|:...:.|  |...::
  Fly   293 QM----------QKLQHNGLDTI-NGSP-----YIQTESALMFDSVYAFANGLHFLNLDNHQNFY 341

  Fly   132 ILGSGRESLPVEQLIDQLLSGYRMGIDADITVALRG-----PDNASMLFYDVYRISRQANTPLII 191
            |...   |...:|..:..:|.|.. |:|.||..|.|     ....::...|:.::.::.     |
  Fly   342 IKNL---SCTSDQTWNDGISLYNQ-INAAITDGLTGTVQFVEGRRNIFKLDILKLKQEK-----I 397

  Fly   192 EKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIGSTVLT--EKPPGFGDMEYLADDKQLQQLD 254
            :|.|.|....|.    |..:.......|..|:||:   |:|  |:|     ...:.:||.|....
  Fly   398 QKVGYWHPDDGV----NISDPTAFYDSNIANITLV---VMTREERP-----YVMVKEDKNLTGNL 450

  Fly   255 PMQRKTYQLFQLVERMFNLSLAISLT--DKWGELL-DNGSWSGVMGQVTSREADFAVCPIRFVLD 316
            ..:.....|.:.:.........|.|.  :.:|..: :..||:|::.::..|.||.||..:.....
  Fly   451 RFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYA 515

  Fly   317 RQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERM 380
            |:..:.::.......|..||:.|.....:.. |..||:.::|..|||    :.||:.|.:.:...
  Fly   516 RESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLA----AYILVSFALFVMAR 576

  Fly   381 LSN---------------MENRFSF---VWFTMLETYLQQGPA-NEIFRLFSTRLLISLSCIFSF 426
            .|.               :||:||.   .|| :..|:|:||.. |.  :..|||::......|..
  Fly   577 FSPYEWKNPHPCYKETDIVENQFSISNSFWF-ITGTFLRQGSGLNP--KATSTRIVGGCWFFFCL 638

  Fly   427 MLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVRD----VYVK 487
            :::..|.|.:...|..|  |.|..:::.  |:||...| |||. .:...::....||    :| :
  Fly   639 IIISSYTANLAAFLTVE--RMISPIESA--SDLAEQTE-ISYG-TLEGGSTMTFFRDSKIGIY-Q 696

  Fly   488 KICKSGEHN-----IMSLQQGAERIIQGRFAF---HTAIDRMYRLLLELQMDEAEFCDLQEVMFN 544
            |:.:..|:.     :.:.:.|.:|:::|.:||   .|.:|      ..:|.|    |:|.::...
  Fly   697 KMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLD------YAVQRD----CNLTQIGGL 751

  Fly   545 LPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKW------MVRRPDCSLFKTSQAE- 599
            |  ||   |...|||||||:.::.|:|..:..|::|....||      :..|.|.|  |.|:|.
  Fly   752 L--DSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKS--KESKANA 812

  Fly   600 VDLEH----FAPALFALALAMVASALVFLLELFLHWLPDFRRRLGT 641
            :.:|:    |...|..||||:|.:...|.      |  :.|:.|.|
  Fly   813 LGVENIGGVFVVLLCGLALAVVVAIFEFC------W--NSRKNLNT 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	11/57 (19%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	97/400 (24%)
		Lig_chan	355..602	CDD:278489	75/287 (26%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	44/210 (21%)
		ANF_receptor	61..393	CDD:279440	39/184 (21%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	99/402 (25%)
		Lig_chan	555..829	CDD:278489	78/301 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940