DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and gria1b

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	755	Identity:	154/755 - (20%)
Similarity:	282/755 - (37%)	Gaps:	205/755 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QVKVISWPLIILTAFLRVLQ---------------IESINTNFLELAAFEDFLRSEHLSHVLVVR 54
            ||..|::..:...|||:.:|               :|.:|:....:||.:..|::.|  ::|...
Zfish   170 QVTSINFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYH--YILANL 232

  Fly    55 G-------DDADGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYG-----SPR-----TAVLV 102
            |       :...|...:...|  |.||.    .|.:|...:|.:.:.     ||:     |..|.
Zfish   233 GFLDLNLTEFRKGGANVTGFQ--LMNYT----NPTVSRTIQDWLEFDSKDLKSPKRRLKYTGALT 291

  Fly   103 LNSEHVL------VRRQVFGVASEAGYFNNSLA-----WFILGSGRESLPVEQLIDQL----LSG 152
            .:...|:      :|:|...: |..|.....||     |   |.|   :.:::.:.|:    |:|
Zfish   292 YDGVTVMATAFQNLRKQRIDI-SRRGNAGECLANPPAPW---GQG---IDIQRALQQVQFEGLTG 349

  Fly   153 Y----RMGIDADITVALR--GPDNASMLFYDVYRISRQANTPLIIEKKGLWTHSGGYQKFGNFKN 211
            :    ..|...:.||::.  ||...                    :|.|.|.....|.....:.|
Zfish   350 HVQFNDKGHRTNFTVSVMEFGPSGP--------------------KKVGYWNQREKYVSTATYSN 394

  Fly   212 ----TWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQL---DPMQRKTYQLFQLVER 269
                |:.::.|.::..|::      |.|       |:...|..:||   |..:....:|...:.:
Zfish   395 MLNETFGLQNRTYVVTTIL------EAP-------YVMLKKNHEQLVGNDKYEGYCVELAAEIAK 446

  Fly   270 MFNLSLAISLT--DKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQN 331
            ....|..:.|.  .|:|.. .:...|:|::|::...:||.||.|:...|.|:..:.:|....:..
Zfish   447 HVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLG 511

  Fly   332 IHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLL---------FHVRLERMLSNMEN 386
            |..:.:.|.:|..... |.:||:.::|.|::....|.:::|.         :|...|...::.:|
Zfish   512 ISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQN 576

  Fly   387 R-----------------------------------FSFVWFTMLETYLQQG----PANEIFRLF 412
            :                                   |:.:||: |..::|||    |     |..
Zfish   577 QNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSL 635

  Fly   413 STRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIF 473
            |.|::..:...|:.:::..|.|.:...|..|  |.:..:::..|    :.:|.|..:.......|
Zfish   636 SGRIVGGVWWFFTLIIISSYTANLAAFLTVE--RMVSPIESAEDLAKQTEIAYGTLDGGSTKEFF 698

  Fly   474 TNTSNQLVRDVYVKKICKSGEHNIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE-- 532
            ..:...:...::  ...||.|..:.  :..:|..|:  .:|::|:          |||..|:|
Zfish   699 RRSKIAVFEKMW--SYMKSAEPTVFVKTTDEGVVRVRKSKGKYAY----------LLESTMNEYI 751

  Fly   533 --AEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC-- 590
              .:.||..:|..||  ||   |...||||..|..:..|:|.....|||.....||...:.:|
Zfish   752 EQRKPCDTMKVGGNL--DSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 814

  Fly   591 ----SLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE 626
                |..|||  .:.|.:.|...:.|...:..:.||.|:|
Zfish   815 GGGDSKDKTS--ALSLSNVAGVFYILIGGLGLAMLVALVE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	14/80 (18%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	88/430 (20%)
		Lig_chan	355..602	CDD:278489	65/315 (21%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	48/251 (19%)
		ANF_receptor	41..368	CDD:279440	43/212 (20%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	91/442 (21%)
		Lig_chan	536..842	CDD:278489	68/329 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940