DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and Ir40a

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	139/752 - (18%)
Similarity:	260/752 - (34%)	Gaps:	217/752 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IILTAFLRVLQIESINTNFLELAA-------------FEDFLRSEHLSHVLVVRGDDADGDWKIE 65
            |.||..:|.||..|:....|...|             .:|||:..|.|
  Fly    34 IALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRS----------------- 81

  Fly    66 CHQKLLANYR-VQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLA 129
                   ||: |.|.:.|:.....:....|:.....|:|:..:.|:.      :....:..:.|:
  Fly    82 -------NYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLN------SLHDRHLGHRLS 133

  Fly   130 WFILGSGRESLPVEQLIDQLLSGYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKK 194
            .||...|....|..::|       |......:.|..|....|..::|:..|....:...|:
  Fly   134 LFIFYWGARWPPSSRVI-------RFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLV---- 187

  Fly   195 GLWTHSG---GYQK----------FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEY--- 243
             .| :.|   |.|:          :.|||.      |.| .|.:..|      ||.|. :.|
  Fly   188 -NW-YDGDNLGLQRIPLLPTALSVYANFKG------RTF-RVPVFHS------PPWFW-VTYCNN 236

  Fly   244 -LADDKQLQQLDPMQR--------KTYQLFQLVERMFNLSLAI---------SLTDKWGELLDNG 290
             ..:|::...||.:::        :.::|..|:.:..|.....         |:..:.|: ..|.
  Fly   237 SFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK-DSND 300

  Fly   291 SWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQ 355
            |::|.:|.:.|.:|||.:..:....:|:..:::|......:..|....|||.:.......|....
  Fly   301 SFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQD 365

  Fly   356 VW-WCVLALVTGSTIL------------------------LLFHV--------RLERM-----LS 382
            :| ..:|.::....|.                        |..|:        ||.::     ||
  Fly   366 IWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLS 430

  Fly   383 --NMENRF--SFVWFTMLETYLQQGPANEIFRLFSTRLLISLSCI-FSFMLMQFYGAFIVGSLLS 442
              .|.::.  ..:||| |..:|:|. .||:...:..:.|..:..| .:::|...|.|    .|.|
  Fly   431 AHQMPHQLFQKCIWFT-LRLFLKQS-CNELHNGYRAKFLTIVYWIAATYVLADVYSA----QLTS 489

  Fly   443 ESAR--------SIVNLQ-ALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498
            :.||        ::..|| |:......:.:|..|.:..:..| ..:|.|.:|...     ...::
  Fly   490 QFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLEN-GTELFRQLYALM-----RQQVI 548

  Fly   499 SLQQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNL-PYDSGS----------- 551
            :..||         .|..:::...:|:.|...|:|.....:.:.||: .|.|.:
  Fly   549 NDPQG---------FFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRY 604

  Fly   552 ---VMPKGSPWREHLAHALLHFRATGLL----------QYND------KKWMVRRPDCSLFKTSQ 597
               .:..|.|:...|.:.|:....:|:|          ||.:      .|..|:..:...:..::
  Fly   605 SAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTE 669

  Fly   598 -------AEVDLEHFAPALFALALAMVASALVFLLEL 627
                   :.::|.....|..||.:..:|:.::.|||:
  Fly   670 SYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEI 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	9/58 (16%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	84/464 (18%)
		Lig_chan	355..602	CDD:278489	57/336 (17%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	26/130 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	18/93 (19%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	26/155 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930